Details for Patent: 8,454,994

Title:	Stable pharmaceutical composition and methods of using same
Abstract:	The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Inventor(s):	Manku; Mehar (England, GB), Osterloh; Ian (Kent, GB), Wicker; Pierre (Mystic, CT), Braeckman; Rene (Richboro, PA), Soni; Paresh (Mystic, CT)
Assignee:	Amarin Pharmaceuticals Ireland Limited (Dublin, IE)
Filing Date:	Sep 13, 2012
Application Number:	13/614,111
Claims:	1. A method of treating mixed dyslipidemia in a subject on statin therapy comprising, administering to the subject 2500 mg to 5000 mg daily of fatty acids, at least about 95% by weight of which are ethyl eicosapentaenoate, wherein upon 12 weeks of said administration the subject exhibits a reduction in triglycerides of at least 15% and a reduction in LDL-C of at least 5% compared to placebo control. 2. The method of claim 1 wherein upon 12 weeks of said administration the subject exhibits a reduction in fasting triglycerides of at least 20% compared to placebo control. 3. The method of claim 1 wherein upon 12 weeks of said administration the subject exhibits a reduction in fasting apolipoprotein B compared to placebo control. 4. The method of claim 1 wherein upon 12 weeks of said administration the subject exhibits a reduction in fasting VLDL-C compared to placebo control. 5. The method of claim 1 wherein upon 12 weeks of said administration the subject exhibits a reduction in fasting VLDL-C of at least 10% compared to placebo control. 6. The method of claim 1 where the ethyl eicosapentaenoate is administered to the subject in capsules each comprising about 900 mg to about 1 g of ethyl eicosapentaenoate. 7. The method of claim 1 where the ethyl eicosapentaenoate is administered to the subject in capsules each comprising about 1 g of ethyl eicosapentaenoate.