Details for Patent: 8,445,479
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Title: | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity |
Abstract: | The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic syndromes, and to a method of treating diseases involving deregulated FLT3 receptor tyrosine kinase activity. |
Inventor(s): | Griffin; James Douglas (Brookline, MA), Manley; Paul William (Arlesheim, CH) |
Assignee: | Novartis AG (Basel, CH) Dana-Farber-Cancer Institute Inc. (Boston, MA) |
Filing Date: | Jun 15, 2012 |
Application Number: | 13/524,340 |
Claims: | 1. A method for treating a mammal suffering from myelodysplastic syndrome comprising administering to a mammal in need of such treatment a therapeutically effective amount of N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9- ,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiaz- onin-11-yl]-N-methylbenzamide of the formula (VII): ##STR00007## or a salt thereof. 2. A method according to claim 1, wherein the therapeutically effective amount of the compound of formula VII is administered to a mammal subject 7 to 4 times a week or about 100% to about 50% of the days during a period of from one to six weeks, followed by a period of one to three weeks, wherein the agent is not administered and this cycle being repeated for from 1 to several cycles. 3. A method according to claim 1, wherein 100 to 300 mg of the compound of formula VII is administered daily. 4. A method according to claim 3, wherein 225 mg of the compound of formula VII is administered daily. 5. A method according to claim 1, wherein the compound of formula VII is administered orally. 6. A method according to claim 5, wherein the compound of formula VII is administered as a microemulsion, soft gel or solid dispersion. 7. A method according to claim 6, wherein the compound of formula VII is administered as a microemulsion. |