.

Deeper Knowledge, Faster

  • Analyze global market entry opportunities
  • Uncover prior art in expired and abandoned patents
  • Set up watchlists for daily email updates

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Express Scripts
Teva
Chubb
Cipla
Baxter
UBS
US Department of Justice
AstraZeneca
Novartis
Harvard Business School

Generated: June 26, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,367,852

« Back to Dashboard

Details for Patent: 8,367,852

Title:Preparation of bile acids and intermediates thereof
Abstract: Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
Inventor(s): Prasad; Achampeta Rathan (Hyderabad, IN), Swaringen, Jr.; Roy A. (Durham, NC), Reid; John Gregory (Niskayuma, NY), Moriarty; Robert M. (Michiana Shores, IN), Sahoo; Akhila Kumar (Bhubaneswar, IN)
Assignee: Kythera Biopharmaceuticals, Inc. (Calabasas, CA)
Filing Date:May 25, 2011
Application Number:13/115,889
Claims:1. A method for preparing deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof: ##STR00029## said method comprising (a) reacting compound 1.3 ##STR00030## with a two carbon olefination reagent under olefin forming conditions to form compound 1.5 ##STR00031## (b) converting compound 1.5 to a compound of formula 1.6 wherein P is a protecting group ##STR00032## (c) reacting a compound of formula 1.6 with an alkylpropiolate or an alkyl acrylate CH.sub.2.dbd.CHC(O)OR wherein R is alkyl in the presence of a Lewis acid to form a compound of formula 1.7 wherein P is a protecting group, R is a alkyl, and the dashed line ---- is a single or double bond; ##STR00033## (d) reacting a compound of formula 1.7 with H.sub.2 under hydrogenation conditions to form a compound of formula 1.8 wherein P is a protecting group and R is alkyl ##STR00034## (e) reacting compound of formula 1.8 with an oxidizing agent to form a compound of formula 1.9 wherein P is a protecting group and R is alkyl ##STR00035## (f) reacting a compound of formula 1.9 with H.sub.2 under hydrogenation conditions to form compound of formula 2.0 wherein P is a protecting group and R is alkyl ##STR00036## (g) reacting compound of formula 2.0 with a reducing agent to form a compound of formula 2.1 wherein P is a protecting group and R is alkyl ##STR00037## (h) exposing compound of formula 2.1 to deprotection and hydrolysis conditions to form deoxycholic acid.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Merck
Harvard Business School
Moodys
Express Scripts
QuintilesIMS
Novartis
US Army
Julphar
Teva
US Department of Justice

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot