Details for Patent: 8,324,207
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Title: | Modulators of ATP-binding cassette transporters |
Abstract: | Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. |
Inventor(s): | Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Oceanside, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA), van Goor; Fredrick (San Diego, CA) |
Assignee: | Vertex Pharmaceuticals Incorporated (Cambridge, MA) |
Filing Date: | Mar 23, 2011 |
Application Number: | 13/069,889 |
Claims: | 1. A method of treating or lessening the severity of a disease in a patient, wherein said disease is selected from hereditary emphysema, or dry-eye disease, said method comprising the step of administering to said patient an effective amount of a compound selected from the following TABLE-US-00012 ##STR00703## 423 ##STR00704## 424 ##STR00705## 425 ##STR00706## 426 ##STR00707## 427 ##STR00708## 428 ##STR00709## 429 ##STR00710## 430 ##STR00711## 431 ##STR00712## 432 ##STR00713## 433 ##STR00714## 434 ##STR00715## 435 ##STR00716## 436 ##STR00717## 437 ##STR00718## 438 ##STR00719## 439 ##STR00720## 440 ##STR00721## 441 ##STR00722## 442 ##STR00723## 443 ##STR00724## 444 ##STR00725## 445 ##STR00726## 446 ##STR00727## 447 ##STR00728## 448 ##STR00729## 449 ##STR00730## 450 ##STR00731## 451 ##STR00732## 452 ##STR00733## 453 ##STR00734## 454 ##STR00735## 455 ##STR00736## 456 ##STR00737## 457 ##STR00738## 458 ##STR00739## 459 ##STR00740## 460 ##STR00741## 461 ##STR00742## 462 ##STR00743## 463 ##STR00744## 465 ##STR00745## 466 ##STR00746## 467 ##STR00747## 468 ##STR00748## 469 ##STR00749## 470 ##STR00750## 471 ##STR00751## 472 ##STR00752## 473 ##STR00753## 474 ##STR00754## 475 ##STR00755## 476 ##STR00756## 477 ##STR00757## 478 ##STR00758## 479 ##STR00759## 480 ##STR00760## 481 ##STR00761## 482 ##STR00762## 483 ##STR00763## 484 ##STR00764## 485 ##STR00765## 486 ##STR00766## 487 ##STR00767## 488 ##STR00768## 489 ##STR00769## 490 ##STR00770## 491 ##STR00771## 492 ##STR00772## 493 ##STR00773## 494 ##STR00774## 495 ##STR00775## 496 ##STR00776## 497 ##STR00777## 498 ##STR00778## 499 ##STR00779## 500 ##STR00780## 501 ##STR00781## 502 ##STR00782## 503 ##STR00783## 504 ##STR00784## 505 ##STR00785## 506 ##STR00786## 507 ##STR00787## 508 ##STR00788## 509 ##STR00789## 510 ##STR00790## 511 ##STR00791## 512 ##STR00792## 513 ##STR00793## 514 ##STR00794## 515 ##STR00795## 516 ##STR00796## 517 ##STR00797## 518 ##STR00798## 519 ##STR00799## 520 ##STR00800## 521 ##STR00801## 522 ##STR00802## 523 ##STR00803## 524 ##STR00804## 525 ##STR00805## 526 ##STR00806## 527 ##STR00807## 528 2. The method of claim 1, wherein the disease is dry-eye disease. 3. The method of claim 1, wherein the disease is hereditary emphysema. |