.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 8,324,207

« Back to Dashboard

Details for Patent: 8,324,207

Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Oceanside, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA), van Goor; Fredrick (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Cambridge, MA)
Filing Date:Mar 23, 2011
Application Number:13/069,889
Claims:1. A method of treating or lessening the severity of a disease in a patient, wherein said disease is selected from hereditary emphysema, or dry-eye disease, said method comprising the step of administering to said patient an effective amount of a compound selected from the following TABLE-US-00012 ##STR00703## 423 ##STR00704## 424 ##STR00705## 425 ##STR00706## 426 ##STR00707## 427 ##STR00708## 428 ##STR00709## 429 ##STR00710## 430 ##STR00711## 431 ##STR00712## 432 ##STR00713## 433 ##STR00714## 434 ##STR00715## 435 ##STR00716## 436 ##STR00717## 437 ##STR00718## 438 ##STR00719## 439 ##STR00720## 440 ##STR00721## 441 ##STR00722## 442 ##STR00723## 443 ##STR00724## 444 ##STR00725## 445 ##STR00726## 446 ##STR00727## 447 ##STR00728## 448 ##STR00729## 449 ##STR00730## 450 ##STR00731## 451 ##STR00732## 452 ##STR00733## 453 ##STR00734## 454 ##STR00735## 455 ##STR00736## 456 ##STR00737## 457 ##STR00738## 458 ##STR00739## 459 ##STR00740## 460 ##STR00741## 461 ##STR00742## 462 ##STR00743## 463 ##STR00744## 465 ##STR00745## 466 ##STR00746## 467 ##STR00747## 468 ##STR00748## 469 ##STR00749## 470 ##STR00750## 471 ##STR00751## 472 ##STR00752## 473 ##STR00753## 474 ##STR00754## 475 ##STR00755## 476 ##STR00756## 477 ##STR00757## 478 ##STR00758## 479 ##STR00759## 480 ##STR00760## 481 ##STR00761## 482 ##STR00762## 483 ##STR00763## 484 ##STR00764## 485 ##STR00765## 486 ##STR00766## 487 ##STR00767## 488 ##STR00768## 489 ##STR00769## 490 ##STR00770## 491 ##STR00771## 492 ##STR00772## 493 ##STR00773## 494 ##STR00774## 495 ##STR00775## 496 ##STR00776## 497 ##STR00777## 498 ##STR00778## 499 ##STR00779## 500 ##STR00780## 501 ##STR00781## 502 ##STR00782## 503 ##STR00783## 504 ##STR00784## 505 ##STR00785## 506 ##STR00786## 507 ##STR00787## 508 ##STR00788## 509 ##STR00789## 510 ##STR00790## 511 ##STR00791## 512 ##STR00792## 513 ##STR00793## 514 ##STR00794## 515 ##STR00795## 516 ##STR00796## 517 ##STR00797## 518 ##STR00798## 519 ##STR00799## 520 ##STR00800## 521 ##STR00801## 522 ##STR00802## 523 ##STR00803## 524 ##STR00804## 525 ##STR00805## 526 ##STR00806## 527 ##STR00807## 528

2. The method of claim 1, wherein the disease is dry-eye disease.

3. The method of claim 1, wherein the disease is hereditary emphysema.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc