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|Title:||Controlled release and taste masking oral pharmaceutical composition|
|Abstract:||Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.|
|Inventor(s):||Villa; Roberto (Lecco, IT), Pedrani; Massimo (Gignese, IT), Ajani; Mauro (Milan, IT), Fossati; Lorenzo (Milan, IT)|
|Assignee:||Cosmo Technologies Limited (Dublin, IE)|
|Filing Date:||May 02, 2012|
|Claims:||1. A controlled release oral pharmaceutical composition comprising: (1) a tablet core comprising: a) budesonide in an amount effective for treatment of inflammatory bowel disease in the gastrointestinal tract, b) stearic acid; c) lecithin; and d) hydroxypropyl cellulose; and (2) a gastro-resistant coating on said tablet core, said coating comprising at least one methacrylic acid polymer. |
2. The composition of claim 1, wherein said tablet core further comprises microcrystalline cellulose, lactose, and magnesium stearate.
3. The composition of claim 1, comprising 9 mg of budesonide.
4. The composition of claim 2, comprising 9 mg of budesonide.