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|Title:||Rapidly disintegrating tablet containing polyvinyl alcohol|
|Abstract:||The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.|
|Inventor(s):||Morita; Yutaka (Saitama, JP), Yasui; Masanobu (Saitama, JP), Ohwaki; Takayuki (Saitama, JP), Tsushima; Yuki (Saitama, JP)|
|Assignee:||Eisai R&D Management Co., Ltd. (Tokyo, JP)|
|Filing Date:||Jul 16, 2007|
|Claims:||1. A method for producing a compressed quickly disintegrating tablet, said method comprising the steps of: mixing donepezil hydrochloride with mannitol; kneading the mixture with water including polyvinyl alcohol dissolved therein or with an aqueous organic solvent; subjecting the kneaded mixture to a compression-molding; and producing said quickly disintegrating and compressed tablet comprising donepezil hydrochloride, mannitol and polyvinyl alcohol, wherein said mannitol is mixed in an amount of 0.8 part by weight or more to 1 part by weight of said tablet, and said polyvinyl alcohol is mixed in an amount of 0.001 to 0.05 part by weight to 1 part by weight of said tablet. |
2. The method for producing a compressed quickly disintegrating tablet of claim 1, further comprising: subjecting the kneaded mixture to the compression-molding via a film.
3. The method for producing a compressed quickly disintegrating tablet of claim 1, further comprising the step of filling a mold with the kneaded mixture after the step of the kneading the mixture with water or the aqueous organic solvent.
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