.

Deeper Knowledge, Faster

  • Analyze global market entry opportunities
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Harvard Business School
McKesson
Express Scripts
Johnson and Johnson
McKinsey
Teva
Deloitte
Baxter
Cantor Fitzgerald
Chinese Patent Office

Generated: December 18, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:S-triazolyl .alpha.-mercapto acetanilides as inhibitors of HIV reverse transcriptase
Abstract: A series of S-triazolyl .alpha.-mercaptoacetanilides having general structure (1) are provided, where Q is CO.sub.2H, CONR.sub.2, SO.sub.3H, or SO.sub.2NR.sub.2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections. ##STR00001##
Inventor(s): Girardet; Jean-Luc (San Diego, CA), Koh; Yung Hyo (Irvine, CA), De La Rosa; Martha (San Diego, CA), Gunic; Esmir (San Diego, CA), Hong; Zhi (Irvine, CA), Lang; Stanley (Laguna Niguel, CA), Kim; Hong Woo (San Diego, CA)
Assignee: Ardea Biosciences, Inc. (San Diego, CA)
Filing Date:Jun 30, 2011
Application Number:13/174,538
Claims:1. A compound of Formula A'' ##STR00326## wherein R.sup.1 is C.sub.1-3 alkyl, CF.sub.3, CHF.sub.2, CH.sub.2F, Cl, Br, NH.sub.2, or hydrogen; R.sup.2 is 4-Q-naphth-1-yl or 4-Q-phen-1-yl; Q is C.sub.2-5 alkyl; W is S, O or an optionally substituted amine; R.sup.3 is C.sub.1-3 alkyl, CF.sub.3, CHF.sub.2, CH.sub.2F, Cl, Br; and R.sup.4 is COR' or S(O).sub.2R', wherein R' is NH.sub.2 or NH(alkyl).

2. The compound of claim 1, where W is S.

3. The compound of claim 1, wherein R.sup.1 is other than H.

4. The compound of claim 1, wherein Q is ethyl.

5. The compound of claim 1, wherein R.sup.3 is chloro or methyl.

6. The compound of claim 1, which is 2-[5-bromo-4-(4-ethyl-naphthalen-1-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-- (2-chloro-4-sulfamoyl-phenyl)-acetamide or 2-[5-bromo-4-(4-ethyl-naphthalen-1-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-- (2-chloro-4-carbamoyl-phenyl)-acetamide.
« Back to Dashboard

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

Baxter
Argus Health
Julphar
UBS
Cipla
US Department of Justice
Dow
QuintilesIMS
Mallinckrodt
Daiichi Sankyo

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

botpot