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Last Updated: March 28, 2024

Details for Patent: 8,241,243


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Title:Needleless injector drug capsule and a method for filling thereof
Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
Inventor(s): William; Henry (Cambridge, GB), Andrew; Lewis (Cambridge, GB)
Assignee: Zogenix, Inc. (Emeryville, CA)
Filing Date:Nov 21, 2002
Application Number:10/496,357
Claims:1. A needle free injector drug capsule, comprising: a container comprised of borosilicate glass strengthened with ion exchange; and a liquid formulation in the container, wherein the liquid formulation is comprised of a drug, and the liquid formulation has been purged by an inert gas having a solubility of 0.5 cm.sup.3 to 25 cm.sup.3 in 100 cm.sup.3 of the liquid formulation; wherein the inert gas solubility in the formulation over a range of temperatures from 0.degree. C. to 30.degree. C. is such that the inert gas does not come out of solution during temperature cycling.

2. A needle free injector drug capsule as claimed in claim 1, wherein the inert gas is selected from the group consisting of helium, argon, neon, krypton, xenon, nitrogen, a chlorofluorocarbon, a hydrofluorocarbons, and a mixture thereof.

3. A needle free injector drug capsule as claimed in claim 1, wherein the inert gas does not include helium.

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