.

BioPharmaceutical Business Intelligence

  • Analyze global market entry opportunities
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

McKesson
Mallinckrodt
Chinese Patent Office
Express Scripts
Queensland Health
Merck
Cerilliant
Fish and Richardson
US Department of Justice
AstraZeneca

Generated: November 23, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Dipeptidyl peptidase inhibitors
Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: ##STR00001## wherein M is N or CR.sub.4; Q.sup.1 and Q.sup.2 are each independently selected from the group consisting of CO, SO, SO.sub.2, and C.dbd.NR.sub.9; and each L, X, R.sub.1, R.sub.2, and R.sub.3 are as defined herein.
Inventor(s): Feng; Jun (Carlsbad, CA), Gwaltney; Stephen L. (San Diego, CA), Stafford; Jeffrey A. (San Diego, CA), Zhang; Zhiyuan (San Diego, CA), Elder; Bruce J. (Wynantskill, NY), Isbester; Paul K. (Castleton, NY), Palmer; Grant J. (Clifton Park, NY), Salsbury; Jonathon S. (Albany, NY), Ulysse; Luckner G. (Albany, NY)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Filing Date:Oct 30, 2007
Application Number:11/928,944
Claims:1. A compound of the formula: 2-(6-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-benzonitrile.

2. A compound of the formula: 2-(6-Chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-benzo- nitrile.

3. A compound of the formula: 2-(6-Chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-4-flu- oro-benzonitrile.

4. A compound selected from the group consisting of: 2-((6-chloro-3-ethyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzo- nitrile; 1-(2-bromobenzyl)-6-chloropyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-iodobenzyl)pyrimidine-2,4(1H,3H)-dione; 1-(2-bromo-5-fluorobenzyl)-6-chloropyrimidine-2,4(1H,3H)-dione; 1-(2-bromo-5-fluorobenzyl)-6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-5-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-5-fluorobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-4-fluorobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione; 1-(2-bromobenzyl)-6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione; 2-((6-chloro-3-(3-cyanobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)me- thyl)benzonitrile; 2,2'-(6-chloro-2,4-dioxopyrimidine-1,3(2H,4H)-diyl)bis(methylene)dibenzon- itrile; 2-((6-chloro-3-(4-cyanobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H- )-yl)methyl)benzonitrile; 2-((3-((1H-benzo[d]imidazol-2-yOmethyl)-6-chloro-2,4-dioxo-3,4-dihydropyr- imidin-1(2H)-yl)methyl)benzonitrile; 2-((3-(4-(1H-pyrazol-1-yl)benzyl)-6-chloro-2,4-dioxo-3,4-dihydropyrimidin- -1(2H)-yl)methyl)benzonitrile; 2-((3-(3-(1H-pyrrol-1-yl)benzyl)-6-chloro-2,4-dioxo-3,4-dihydropyrimidin-- 1(2H)-yl)methyl)benzonitrile; 2-((4-chloro-3-(2-cyanobenzyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)me- thyl)thiophene-3-carbonitrile; methyl 3-((4-chloro-3-(2-cyanobenzyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)me- thyl)benzoate; 1,3-bis(2-bromo-5-fluorobenzyl)-6-chloropyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2,5-dichlorobenzyl)pyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2,5-dichlorobenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-3,6-difluorobenzyl)pyrimidine-2,4(1H,3H)-dione; 6-chloro-1-(2-chloro-3,6-difluorobenzyl)-3-methylpyrimidine-2,4(1H,3H)-di- one; and 2-(6-Chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy- l)-4-fluoro-benzonitrile.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving leading biopharmaceutical companies globally:

Colorcon
US Army
QuintilesIMS
Express Scripts
Cipla
Medtronic
Dow
Cantor Fitzgerald
Healthtrust
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot