Details for Patent: 8,158,580
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Title: | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin |
Abstract: | Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions. |
Inventor(s): | Judice; J. Kevin (El Granada, CA), Shaw; Jeng-Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselmo, CA) |
Assignee: | Theravance, Inc. (South San Francisco, CA) |
Filing Date: | Apr 29, 2009 |
Application Number: | 12/431,940 |
Claims: | 1. A pharmaceutical composition comprising: (a) a lipidated vancomycin derivative, or a pharmaceutically-acceptable salt thereof; and (b) a cyclodextrin selected from hydroxypropyl-.beta.-cyclodextrin and sulfobutyl ether .beta.-cyclodextrin. 2. The pharmaceutical composition of claim 1, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin. 3. The pharmaceutical composition of claim 1, wherein the cyclodextrin is sulfobutyl ether .beta.-cyclodextrin. |