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Details for Patent: 8,148,554

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Details for Patent: 8,148,554

Title:Methods and compositions for use in treating cancer
Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
Inventor(s): Seletsky; Boris M. (Andover, MA), Yu; Melvin J. (Andover, MA), Zheng; Wanjun (Londonderry, NH)
Assignee: Eisai R&D Management Co., Ltd. (Tokyo, JP)
Filing Date:Aug 12, 2010
Application Number:12/855,412
Claims:1. A compound having the formula: ##STR00021##

2. A compound having the formula: ##STR00022##

3. A compound having the formula: ##STR00023##

4. A compound having the formula: ##STR00024##

5. A compound having the formula: ##STR00025##

6. A method of preparing: ##STR00026## or a pharmaceutically acceptable salt thereof, the method comprising the steps of synthesizing a compound selected from the group consisting of ##STR00027## ##STR00028## and synthesizing B1939 or the pharmaceutically acceptable salt from the compound.

7. A method of preparing: ##STR00029## or a pharmaceutically acceptable salt thereof, the method comprising the steps of reacting ##STR00030## under conditions to produce: ##STR00031## reacting ER804029 under conditions to produce: ##STR00032## reacting ER804030 under conditions to produce: ##STR00033## reacting B2304 under conditions to produce: ##STR00034## reacting B2303, B2303 under conditions to produce: ##STR00035## reacting B2301 under conditions to produce: ##STR00036## and reacting B1793 under conditions to produce B1939 or the pharmaceutically acceptable salt.
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