Details for Patent: 8,138,353

Title:	Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
Abstract:	Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
Inventor(s):	Hirth; Bradford H. (Littleton, MA), Siegel; Craig (Woburn, MA)
Assignee:	Genzyme Corporation (Cambridge, MA)
Filing Date:	Jul 06, 2010
Application Number:	12/830,962
Claims:	1. A compound represented by the following structural formula: ##STR00032## the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein: R.sub.1 is a substituted or unsubstituted aromatic group; R.sub.2 and R.sub.3 are independently --H, a substituted or unsubstituted aliphatic group or, taken together with the nitrogen atom to which they are bonded, are a substituted or unsubstituted non-aromatic heterocyclic ring; R.sub.4 is O or H.sub.2; and R.sub.5 is a substituted or unsubstituted aromatic group. 2. The compound of claim 1 wherein: R.sub.1 and R.sub.5 are independently a substituted or unsubstituted phenyl group; and R.sub.2 and R.sub.3 are independently --H, an unsubstituted C1-C5 alkyl group or, taken together with the nitrogen atom to which they are bonded, are an unsubstituted C3-C10 non-aromatic heterocyclic ring. 3. The compound of claim 2 wherein R.sub.5 is a phenyl group. 4. The compound of claim 3 wherein R.sub.2 and R.sub.3 taken together with the nitrogen atom to which they are bonded, are pyrrolidinyl, piperazinyl, azetidinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, piperidinyl or N-phenylpiperazinyl. 5. A compound represented by the following structural formula: ##STR00033## the enantiomer of the compound, a salt of the compound, or a salt of the enantiomer, wherein R.sub.1 is a substituted or unsubstituted phenyl group and R.sub.4 is H.sub.2 or O. 6. The compound of claim 5 wherein the phenyl group represented by R.sub.1 is substituted with --OCH.sub.2O--, --OCH.sub.2CH.sub.2O--, halo, --O(lower alkyl), --OH, lower alkyl thiol, --O(phenyl), --OCH.sub.2(phenyl), --O--CH.sub.2-- (phenyl), lower alkyl, amino, lower alkyl amino or lower dialkyl amino.