Details for Patent: 8,124,630
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Title: | .omega.-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
Abstract: | This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. |
Inventor(s): | Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Orange, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy B. (Nishinomiya, JP), Scott; William J. (Guilford, CT), Smith; Roger A. (Madison, CT), Wood; Jill E. (North Haven, CT), Natero; Reina (Hamden, CT) |
Assignee: | Bayer Healthcare LLC (Tarrytown, NY) |
Filing Date: | Nov 27, 2001 |
Application Number: | 09/993,647 |
Claims: | 1. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00186## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00187## or a pharmaceutically acceptable salt thereof. 2. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00188## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00189## or a pharmaceutically acceptable salt thereof. 3. A method of claim 1 for the treatment of carcinoma of the lung in a human in need thereof. 4. A method of claim 1 for the treatment of carcinoma of the pancreas in a human in need thereof. 5. A method of claim 1 for the treatment of carcinoma of the thyroid in a human in need thereof. 6. A method of claim 1 for the treatment of carcinoma of the bladder in a human in need thereof. 7. A method of claim 1 for the treatment of carcinoma of the colon in a human in need thereof. 8. A method for the treatment of carcinoma of the lung, pancreas, thyroid, bladder or colon in a human or animal in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00190## 9. A method for the treatment of myeloid leukemia in a human in need thereof comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-- pyridyloxy)phenyl)urea of the formula: ##STR00191## 10. A method of claim 8 for the treatment of carcinoma of the lung in a human in need thereof. 11. A method of claim 8 for the treatment of carcinoma of the pancreas in a human in need thereof. 12. A method of claim 8 for the treatment of carcinoma of the thyroid in a human in need thereof. 13. A method of claim 8 for the treatment of carcinoma of the bladder in a human in need thereof. 14. A method of claim 8 for the treatment of carcinoma of the colon in a human in need thereof. 15. A method for the treatment of villous colon adenoma comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-carbamoyl-4-pyridyloxy)ph- enyl)urea of the formula: ##STR00192## N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00193## or a pharmaceutically acceptable salt thereof. 16. A method for the treatment of villous colon adenoma comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00194## |