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Details for Patent: 8,106,205

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Details for Patent: 8,106,205

Title:N[S(4-aryl-triazol-3-yl).alpha.-mercaptoacetyl]p-amino benzoic acids as HIV reverse transcriptase inhibitors
Abstract: A series of S-triazolyl .alpha.-mercaptoacetanilides having N-(.alpha.-mercaptoacetyl) p amino benzoic acid derivatives. ##STR00001## are provided, where Q is CO.sub.2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
Inventor(s): Girardet; Jean-Luc (Aliso Viejo, CA), Koh; Yung-hyo (Irvine, CA), De La Rosa; Martha (Fountain Valley, CA), Hong; Zhi (Chapel Hill, NC), Lang; Stanley (Concord Township, OH)
Assignee: Ardea Biosciences, Inc. (San Diego, CA)
Filing Date:Feb 02, 2010
Application Number:12/698,582
Claims:1. A compound selected from the group consisting of: ##STR00278## ##STR00279## wherein Q.sup.1 is CO.sub.1H or SO.sub.3H; and Q.sup.2 is C.sub.3-5 cycloalkyl or C.sub.2-5 alkyl.
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