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Details for Patent: 8,071,737

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Details for Patent: 8,071,737

Title:Nucleic acid ligand complexes
Abstract: This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.
Inventor(s): Gold; Larry (Boulder, CO), Schmidt; Paul (Niwot, CO), Janjic; Nebojsa (Boulder, CO)
Assignee: Glead Sciences, Inc. (Forster City, CA)
Filing Date:Nov 23, 2009
Application Number:12/624,314
Claims:1. A method for imaging a site expressing a Target in a patient, the method comprising: covalently linking a Nucleic Acid Ligand with magnetite, wherein said Nucleic Acid Ligand has a specific binding affinity for said Target; administering said Nucleic Acid Ligand associated with magnetite to a patient; and performing nuclear magnetic resonance (NMR) imaging.
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