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Generated: July 21, 2017
| Title: | Nucleic acid ligand complexes |
| Abstract: | This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound. |
| Inventor(s): | Gold; Larry (Boulder, CO), Schmidt; Paul (Niwot, CO), Janjic; Nebojsa (Boulder, CO) |
| Assignee: | Glead Sciences, Inc. (Forster City, CA) |
| Filing Date: | Nov 23, 2009 |
| Application Number: | 12/624,314 |
| Claims: | 1. A method for imaging a site expressing a Target in a patient, the method comprising: covalently linking a Nucleic Acid Ligand with magnetite, wherein said Nucleic Acid Ligand has a specific binding affinity for said Target; administering said Nucleic Acid Ligand associated with magnetite to a patient; and performing nuclear magnetic resonance (NMR) imaging. |
Serving 500+ biopharmaceutical companies globally:
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