Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Check market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 8,071,617

« Back to Dashboard

Details for Patent: 8,071,617

Title:Modulators of cellular adhesion
Abstract: The present invention provides compounds having formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p, A, B, D, E, L and AR.sup.1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
Inventor(s): Shen; Wang (San Mateo, CA), Barr; Kenneth (Boston, MA), Oslob; Johan D. (Sunnyvale, CA), Zhong; Min (Foster City, CA)
Assignee: SARcode Bioscience Inc. (Brisbane, CA)
Filing Date:Feb 04, 2011
Application Number:13/020,992
Claims:1. A compound of the following structure: ##STR00215## or pharmaceutically acceptable salts thereof; wherein --C(.dbd.O)NHC(R.sup.1)(R.sup.2)R.sup.3 is a moiety having the following structure: ##STR00216## R.sup.3A is hydrogen; R.sup.S is hydrogen; Ar.sub.2 is: ##STR00217## s is an integer of 1; each occurrence of R.sup.P1 is independently hydrogen, halogen, or -GR.sup.G1, wherein G is --SO.sub.2--, or --SO.sub.2NR.sup.G2--; and R.sup.G1 and R.sup.G2 are independently hydrogen, an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic or heteroaromatic moiety; R.sup.B1, R.sup.B2 and R.sup.E are hydrogen; R.sup.4A and R.sup.4B are each Cl; L is C.dbd.O; and AR.sub.1 is ##STR00218## wherein R.sup.Q1 is independently hydrogen, OR.sup.Q3, OCF.sub.3, SR.sup.Q3, halogen, CN, isocyanate, NO.sub.2, CF.sub.3, NR.sup.Q3R.sup.Q4, --SO.sub.2R.sup.Q3, alkyl-NR.sup.Q3R.sup.Q4, alkyl-C(.dbd.O)--NR.sup.Q3R.sup.Q4, alkyl-C(.dbd.O)R.sup.Q3, or an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, heteroaryl, alkylaryl, alkylheteroaryl, heteroalkylaryl, or heteroalkylheteroaryl moiety, wherein each occurrence of R.sup.Q3 and R.sup.Q4 is independently hydrogen, a protecting group, or an aliphatic, heteroaliphatic, aryl or heteroaryl moiety; and r is an integer from 0-6.

2. The compound of claim 1, wherein R.sup.P1 is selected from the group consisting of halogen and -GR.sup.G1, wherein G is --SO.sub.2-- and R.sup.G1 is methyl.

3. The compound of claim 2, wherein R.sup.P1 is selected from the group consisting of F and SO.sub.2CH.sub.3.

4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.

5. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier or diluent.

6. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier or diluent.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.