Details for Patent: 8,034,825
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Title: | Chemically modified small molecules |
Abstract: | The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer. |
Inventor(s): | Bentley; Michael D. (Huntsville, AL), Viegas; Tacey X. (Madison, AL), Goodin; Richard R. (Fayerville, TN), Cheng; Lin (Huntsville, AL), Zhao; Xuan (Huntsville, AL) |
Assignee: | Nektar Therapeutics (San Francisco, CA) |
Filing Date: | Jun 24, 2010 |
Application Number: | 12/822,935 |
Claims: | 1. A compound selected from the group consisting of: 6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol; 6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol; 6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol; and 6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol; or a pharmaceutically acceptable salt thereof, wherein the compound is an .alpha.-6 isomer, a .beta.-6 isomer or a mixture of .alpha.-6 and .beta.-6 isomers. 2. The compound of claim 1, wherein the compound is selected from the group consisting of .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol; .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol; .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol; and .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol; or a pharmaceutically acceptable salt thereof. 3. The compound of claim 2, wherein the compound is .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol or a pharmaceutically acceptable salt thereof. 4. The compound of claim 2, wherein the compound is .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol or a pharmaceutically acceptable salt thereof. 5. The compound of claim 2, wherein the compound is .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol or a pharmaceutically acceptable salt thereof. 6. The compound of claim 2, wherein the compound is .alpha.,.beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol or a pharmaceutically acceptable salt thereof. 7. The compound of claim 1, wherein the compound is selected from the group consisting of .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol; .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol; .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol; and .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol; or a pharmaceutically acceptable salt thereof. 8. The compound of claim 7, wherein the compound is .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol or a pharmaceutically acceptable salt thereof. 9. The compound of claim 7, wherein the compound is .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol or a pharmaceutically acceptable salt thereof. 10. The compound of claim 7, wherein the compound is .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol or a pharmaceutically acceptable salt thereof. 11. The compound of claim 7, wherein the compound is .alpha.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol or a pharmaceutically acceptable salt thereof. 12. The compound of claim 1, wherein the compound is selected from the group consisting of .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol; .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol; .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol; and .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol; or a pharmaceutically acceptable salt thereof. 13. The compound of claim 12, wherein the compound is .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.5-O-naloxol or a pharmaceutically acceptable salt thereof. 14. The compound of claim 12, wherein the compound is .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.6-O-naloxol or a pharmaceutically acceptable salt thereof. 15. The compound of claim 12, wherein the compound is .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.8-O-naloxol or a pharmaceutically acceptable salt thereof. 16. The compound of claim 12, wherein the compound is .beta.-6-CH.sub.3-(OCH.sub.2CH.sub.2).sub.9-O-naloxol or a pharmaceutically acceptable salt thereof. 17. A pharmaceutical composition comprising a compound of any one of claims 1-16 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. |