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BioPharmaceutical Business Intelligence

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Serving leading biopharmaceutical companies globally:

Merck
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Chubb
Farmers Insurance
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Julphar
US Department of Justice
Deloitte
Novartis
Fish and Richardson

Generated: November 18, 2017

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Title:Modulators of cellular adhesion
Abstract: The present invention provides compounds having formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p, A, B, D, E, L and AR.sup.1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
Inventor(s): Shen; Wang (San Mateo, CA), Barr; Kenneth (Boston, MA), Oslob; Johan D. (Sunnyvale, CA), Zhong; Min (Foster City, CA)
Assignee: SAR code Corporation (Brisbane, CA)
Filing Date:Feb 04, 2011
Application Number:13/021,013
Claims:1. A compound of the following structure: ##STR00216## or pharmaceutically acceptable salts thereof; wherein --C(.dbd.O)NHC(R.sup.1)(R.sup.2)R.sup.3 is a moiety having the following structure: ##STR00217## R.sup.3A is hydrogen; R.sup.S is hydrogen; Ar.sub.2 is: ##STR00218## s is an integer of 1; each occurrence of R.sup.P1 is independently hydrogen, halogen, or -GR.sup.G1, wherein G is --SO.sub.2--, or --SO.sub.2NR.sup.G2--; and R.sup.G1 and R.sup.G2 are independently hydrogen, an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aromatic or heteroaromatic moiety; R.sup.B1, R.sup.B2 and R.sup.E are hydrogen; R.sup.4A and R.sup.4B are each Cl; L is C.dbd.O; and AR.sub.1 is ##STR00219##

2. The compound of claim 1, wherein R.sup.P1 is selected from the group consisting of halogen and -GR.sup.G1, wherein G is --SO.sub.2-- and R.sup.G1 is methyl.

3. The compound of claim 2, wherein AR.sub.1 is ##STR00220## and R.sup.P1 is selected from the group consisting of F and SO.sub.2CH.sub.3.

4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.
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Serving leading biopharmaceutical companies globally:

Healthtrust
McKesson
Queensland Health
McKinsey
Cantor Fitzgerald
Harvard Business School
Novartis
Boehringer Ingelheim
Covington
Moodys

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