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Details for Patent: 7,973,160

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Details for Patent: 7,973,160

Title:Nitrogen-containing aromatic derivatives
Abstract: Compounds represented by the following general formula: ##STR00001## [wherein A.sup.g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X.sup.g is --O--, --S--, etc.; Y.sup.g is an optionally substituted C.sub.6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T.sup.g1 is a group represented by the following general formula: ##STR00002## (wherein E.sup.g is a single bond or --N(R.sup.g2)--, R.sup.g1 and R.sup.g2 each independently represent a hydrogen atom, an optionally substituted C.sub.1-6 alkyl group, etc. and Z.sup.g represents a C.sub.1-8 alkyl group, a C.sub.3-8 alicyclic hydrocarbon group, a C.sub.6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.
Inventor(s): Funahashi; Yasuhiro (Nagoya, JP), Haneda; Toru (Ushiku, JP), Kamata; Junichi (Tsukuba, JP), Watanabe; Tatsuo (Inzai, JP), Obaishi; Hiroshi (Tsukuba, JP), Matsui; Junji (Toride, JP)
Assignee: Eisai R&D Management Co., Ltd. (Tokyo, JP)
Filing Date:Oct 02, 2008
Application Number:12/244,227
Claims:1. A compound represented by the following general formula: ##STR01211## wherein R.sup.c13 is a hydrogen atom, cyano, a halogen atom, formyl, an optionally substituted C.sub.1-6 alkyl group, a group represented by the formula: ##STR01212## wherein V.sup.c21 is --CO-- or methylene; V.sup.c22 and V.sup.c23 are each independently a hydrogen atom, optionally substituted C.sub.1-6 alkyl group, optionally substituted C.sub.2-6 alkenyl group, optionally substituted C.sub.2-6 alkynyl group, optionally substituted C.sub.3-8 alicyclic hydrocarbon group, optionally substituted 5- to 14-membered heterocyclic group, optionally substituted 5- to 14-membered aromatic heterocyclic group or optionally substituted C.sub.6-14 aryl group, or a group represented by the formula: --V.sup.c21--O--V.sup.c22 wherein V.sup.c21 and V.sup.c22 have the same definitions as above; X.sup.y2 is an optionally substituted group selected from the group consisting of the following formulas: ##STR01213## wherein Z.sup.12 is a hydrogen atom, optionally substituted C.sub.1-6 alkyl group, optionally substituted C.sub.2-6 alkenyl group, optionally substituted C.sub.2-6 alkynyl group, optionally substituted C.sub.3-8 alicyclic hydrocarbon group, optionally substituted C.sub.6-14 aryl group, optionally substituted 5- to 14-membered heterocyclic group, optionally substituted 5- to 14-membered aromatic heterocyclic group or a group represented by the formula: ##STR01214## wherein Z.sup.31, Z.sup.33 and Z.sup.34 are each independently methylene, --CO--, --NH-- or --O--, and Z.sup.32 is a single bond, methylene, --CO--, --NH-- or --O--, and R.sup.1 and R.sup.2 are each independently a hydrogen atom, optionally substituted C.sub.1-6 alkyl group, optionally substituted C.sub.2-6 alkenyl group, optionally substituted C.sub.2-6 alkynyl group, optionally substituted C.sub.3-8 alicyclic hydrocarbon group, optionally substituted C.sub.2-7 acyl group or optionally substituted C.sub.2-7 alkoxycarbonyl group; and W.sup.11 is an optionally substituted carbon atom or a nitrogen atom; R.sup.c11 is a group represented by the formula --V.sup.c11--V.sup.c12--V.sup.c13, wherein V.sup.c11 is a single bond, oxygen atom, optionally substituted benzene ring, optionally substituted 5- to 14-membered aromatic heterocyclic group or --CO--; V.sup.c12 is a single bond, oxygen atom or optionally substituted C.sub.1-6 alkylene group; and V.sup.c13 is an optionally substituted C.sub.1-6 alkyl group, an optionally substituted C.sub.2-6 alkenyl group, an optionally substituted C.sub.2-6 alkynyl group, an optionally substituted C.sub.3-8 alicyclic hydrocarbon group, hydroxyl, carboxyl, an optionally substituted C.sub.2-7 alkoxycarbonyl group, an optionally substituted 5- to 14-membered heterocyclic group, an optionally substituted 5- to 14-membered aromatic heterocyclic group, an optionally substituted C.sub.6-14 aryl group, a group represented by the formula --NR.sup.c21R.sup.c22, wherein R.sup.c21 and R.sup.c22 are each independently a hydrogen atom or optionally substituted C.sub.1-6 alkyl group, or a hydrogen atom; and R.sup.c12 is a hydrogen atom, optionally substituted C.sub.1-6 alkyl group or optionally substituted C.sub.3-8 alicyclic hydrocarbon group; with the exception of the following compounds (1) and (2): (1) a compound wherein R.sup.1 and R.sup.2 are hydrogen atoms and Z.sup.12 is a C.sub.6-14 aryl group, a 5- to 14-membered heterocyclic group, a C.sub.1-6 alkyl group substituted with a 5- to 14-membered aromatic heterocyclic group, a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, a C.sub.2-6 alkenyl group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, a C.sub.2-6 alkynyl group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, or a C.sub.3-8 alicyclic hydrocarbon group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group; and (2) a compound wherein X.sup.y2 is a group represented by the formula: ##STR01215## wherein Z.sup.12 is a C.sub.6-14 aryl group, a 5- to 14-membered heterocyclic group, a 5- to 14-membered aromatic heterocyclic group, a C.sub.1-6 alkyl group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, a C.sub.2-6 alkenyl group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, a C.sub.2-6 alkynyl group substituted with a 5- to 10-membered heterocyclic group or a C.sub.5-10 alicyclic hydrocarbon group, or a C.sub.3-8 alicyclic hydrocarbon group, a salt thereof or a hydrate of the foregoing.

2. A compound according to claim 1, a salt of the compound or a hydrate of the foregoing, wherein R.sup.c11 is a group represented by the formula: ##STR01216## wherein V.sup.f11 is a single bond, an optionally substituted C.sub.1-6 alkylene group or a group represented by the formula: ##STR01217## and V.sup.f12 is a hydrogen atom, a hydroxyl group, an optionally substituted 5- to 14-membered heterocyclic group, an optionally substituted 5- to 14-membered aromatic heterocyclic group, an optionally substituted C.sub.6-14 aryl group or a group represented by the formula --NR.sup.f21R.sup.f22 wherein R.sup.f21 and R.sup.f22 are each independently a hydrogen atom or an optionally substituted C.sub.1-6 alkyl group.
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