.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,956,063

« Back to Dashboard

Details for Patent: 7,956,063

Title:Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl- ]amino]benzonitrile
Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino- ]benzonitrile and to processes for their preparation.
Inventor(s): Guillemont; Jerome Emile Georges (Ande, FR), Stevens; Paul Theodoor Agnes (Turnhout, BE), Copmans; Alex Herman (Lille, BE), Peeters; Jozef (Beerse, BE), Stappers; Alfred Elisabeth (Oud-Turnhout, BE), Vandecruys; Roger Petrus Gerebern (Westerlo, BE), Stoffels; Paul (Hoostraten, BE)
Assignee: Janssen Pharmaceutica NV (Beerse, BE)
Filing Date:Jul 07, 2008
Application Number:12/168,540
Claims:1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula (I-a) ##STR00004## wherein the compound of formula (I-a) is a polymorphic form selected from the group consisting of: Form B characterized by X-ray powder diffraction peaks at two-theta positions 4.5.degree..+-.0.2.degree., 8.8.degree..+-.0.2.degree., and 12.5.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 10.3.degree..+-.0.2.degree., 14.7.degree..+-.0.2.degree., 20.6.degree..+-.0.2.degree., 22.2.degree..+-.0.2.degree., and 26.1.degree..+-.0.2.degree.; Form C characterized by X-ray powder diffraction peaks at two-theta positions 11.9.degree..+-.0.2.degree., 14.3.degree..+-.0.2.degree. and 22.3.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 12.8.degree..+-.0.2.degree., 18.5.degree..+-.0.2.degree., 21.2.degree..+-.0.2.degree., 24.3.degree..+-.0.2.degree., and 26.0.degree..+-.0.2.degree.; and Form D characterized by X-ray powder diffraction peaks at two-theta positions 6.6.degree..+-.0.2.degree., 11.6.degree..+-.0.2.degree., and 17.1.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 15.0.degree..+-.0.2.degree., 19.2.degree..+-.0.2.degree., 20.5.degree..+-.0.2.degree., 21.6.degree..+-.0.2.degree., and 29.8.degree..+-.0.2.degree..

2. A pharmaceutical composition according to claim 1, wherein the composition is a solid composition.

3. A pharmaceutical composition according to claim 1 further comprising a wetting agent.

4. A pharmaceutical composition according to claim 3 wherein the wetting agent is Tween.

5. A pharmaceutical composition according claim 1 wherein the composition is in the form of a tablet.

6. A pharmaceutical composition according to claim 5 which is film-coated.

7. A process for preparing a pharmaceutical composition comprising (1) a pharmaceutically acceptable carrier comprising a binder; a wetting agent; a diluent; a disintegrant; optionally a glidant; and optionally a lubricant; and (2) a compound of formula (I-a) ##STR00005## wherein the compound of formula (I-a) is a polymorphic form selected from the group consisting of: Form B characterized by x-ray powder diffraction peaks at two-theta positions 4.5.degree..+-.0.2.degree., 8.8.degree..+-.0.2.degree., and 12.5.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 10.3.degree..+-.0.2.degree., 14.7.degree..+-.0.2.degree., 20.6.degree..+-.0.2.degree., 22.2.degree..+-.0.2.degree., and 26.1.degree..+-.0.2.degree.; Form C characterized by X-ray powder diffraction peaks at two-theta positions 11.9.degree..+-.0.2.degree., 14.3.degree..+-.0.2.degree. and 22.3.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 12.8.degree..+-.0.2.degree., 18.5.degree..+-.0.2.degree., 21.2.degree..+-.0.2.degree., 24.3.degree..+-.0.2.degree., and 26.0.degree..+-.0.2.degree.; Form D characterized by X-ray powder diffraction peaks at two-theta positions 6.6.degree..+-.0.2.degree., 11.6.degree..+-.0.2.degree., and 17.1.degree..+-.0.2.degree., and further characterized by X-ray powder diffraction peaks at two-theta positions 15.0.degree..+-.0.2.degree., 19.2.degree..+-.0.2.degree., 20.5.degree..+-.0.2.degree., 21.6.degree..+-.0.2.degree., and 29.8.degree..+-.0.2.degree.; said process comprising the following steps: (i) dry blending the compound of formula I(a) and part of the diluent; (ii) preparing a binder solution by dissolving the binder and the wetting agent in the binder solution; (iii) spraying the binder solution obtained in step (ii) on the mixture obtained in step (i) to form a wet powder; (iv) drying the wet powder obtained in step (iii) followed by sieving and optionally mixing; (v) mixing the remaining part of the diluent, the disintegrant and the optional glidant in the mixture obtained in step (iv); (vi) optionally adding the lubricant to the mixture obtained in step (v); (vii) compressing the mixture obtained in step (vi) into a tablet; and (viii) optionally film-coating the tablet obtained in step (vii).
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc