.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 7,956,030

« Back to Dashboard

Details for Patent: 7,956,030

Title:Method for reducing pain with ziconotide and baclofen
Abstract: The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivacaine, clonidine, hydromorphone, baclofen, fentanyil, buprenorphine, and sufentanil, or its pharmaceutically acceptable salts thereof, wherein the .omega.-conopeptide retains its potency and is physically and chemically compatible with the analgesic compound. A preferred route of administration is intrathecal administration, particularly continuous intrathecal infusion. The present invention is also directed to a pharmaceutical formulation comprising an omega conopeptide, preferably ziconotide, an antioxidant, in combination with an analgesic selected from the group consisting of morphine, bupivacaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine, and sufentanil.
Inventor(s): Ellis; David J. (Los Altos, CA), Miljanich; George P. (Redwood City, CA), Shields; David E. (San Lorenzo, CA)
Assignee: Azur Pharma International Limited (Hamilton, BM)
Filing Date:Oct 05, 2010
Application Number:12/898,525
Claims:1. A method for reducing pain in a patient, comprising: administering to a patient in need thereof 0.6-4.8 .mu.g/day of ziconotide and 22-800 .mu.g/day of baclofen, wherein said administering is continuous intrathecal infusion.

2. The method according to claim 1, wherein said ziconotide is in a solution containing an antioxidant.

3. The method according to claim 2, wherein said antioxidant is methionine.

4. The method according to claim 2, wherein said solution has pH between 4 to 4.5.

5. The method according to claim 2, wherein said baclofen is administered at a constant dosage and said ziconotide is administrated at an increasing dosage each week.

6. The method according to claim 2, wherein said patient is treated for 7 weeks.

7. The method according to claim 2, wherein said administration is performed using a drug dispensing implantable pump.

8. The method according to claim 7, wherein the flow rate of said pump is at least 288 .mu.L/day.

9. A method for treating spasticity in a patient, comprising: administering to a patient in need thereof 0.6-4.8 .mu.g/day of ziconotide and 22-800 .mu.g/day of baclofen, wherein said administering is continuous intrathecal infusion.

10. The method according to claim 9, wherein said ziconotide is in a solution containing an antioxidant.

11. The method according to claim 10, wherein said antioxidant is methionine.

12. The method according to claim 10, wherein said solution has pH between 4 to 4.5.

13. The method according to claim 10, wherein said baclofen is administered at a constant dosage and said ziconotide is administrated at an increasing dosage each week.

14. The method according to claim 10, wherein said patient is treated for 7 weeks.

15. The method according to claim 10, wherein said administration is performed using a drug dispensing implantable pump.

16. The method according to claim 15, wherein the flow rate of said pump is at least 288 .mu.L/day.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc