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Serving hundreds of leading biopharmaceutical companies globally:

Dow
Boehringer Ingelheim
Express Scripts
Baxter
Johnson and Johnson
Medtronic
US Department of Justice
Colorcon
Chubb

Generated: April 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,932,260

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Title:Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
Abstract: The invention provides a class of substituted quinazolinone compounds and methods of treating diseases mediated by PI3K.delta. activity. The disclosed compounds are useful in treating diseases such as bone-resorption disorders; and cancer, especially hematopoietic cancers, lymphomas, multiple myelomas and leukemia. The compounds are also useful in disrupting or inhibiting cellular processes such as leukocyte function or accumulation, neutrophils function, lymphocyte proliferation, and endogenous immune responses.
Inventor(s): Fowler; Kerry W. (Seattle, WA), Huang; Danwen (Sammamish, WA), Kesicki; Edward A. (Bothell, WA), Ooi; Hua Chee (Kirkland, WA), Oliver; Amy (Bothell, WA), Ruan; Fuqiang (Bellevue, WA), Treiberg; Jennifer (Redmond, WA)
Assignee: ICOS Corporation (Bothell, WA)
Filing Date:May 12, 2005
Application Number:11/596,092
Claims:1. A compound of the formula: ##STR00183## (S)-5-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-o- ne; or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 and at least one pharmaceutically acceptable excipient.

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Serving hundreds of leading biopharmaceutical companies globally:

McKesson
Healthtrust
Julphar
Accenture
Colorcon
Baxter
Queensland Health
Cerilliant
Johnson and Johnson

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