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Generated: February 19, 2018

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Title:Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
Abstract: The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof, wherein said dual serotonin norepinephrine reuptake inhibitor compound is characterized by a non-tricyclic structure and an equal or greater inhibition of norepinephrine reuptake than serotonin reuptake. In particular, the use of milnacipran to treat FMS, CFS, and pain is disclosed.
Inventor(s): Kranzler; Jay D. (La Jolla, CA), Rao; Srinivas G. (Encinitas, CA)
Assignee: Cypress Bioscience, Inc. (San Diego, CA)
Filing Date:Feb 22, 2008
Application Number:12/035,820
Claims:1. A method of treating diabetic peripheral neuropathic pain, the method consisting essentially of orally administering to a patient in need thereof an effective amount of an active ingredient, wherein the active ingredient is at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.

2. The method of claim 1, wherein the active ingredient is in a tablet form.

3. The method of claim 1, wherein the effective amount of the active ingredient is an amount between about 25 mg and about 400 mg per day.

4. The method of claim 1, wherein the effective amount of the active ingredient is an amount between about 100 mg and about 250 mg per day.

5. The method of claim 1, wherein the effective amount of the active ingredient is about 100 mg per day.

6. The method of claim 1, wherein the effective amount of the active ingredient is about 200 mg per day.

7. The method of claim 5, wherein the effective amount of the active ingredient is administered as a 50 mg dose twice per day.

8. The method of claim 6, wherein the effective amount of the active ingredient is administered as a 100 mg dose twice per day.

9. The method of claim 8, wherein the effective amount of the active ingredient is administered as two 50 mg doses in the morning and two 50 mg doses in the evening.
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