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Details for Patent: 7,905,230

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Details for Patent: 7,905,230

Title:Metered dose inhaler with lockout
Abstract: An aerosolization device comprises a housing, a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and a metering valve. The metering valve is in communication with the reservoir and is moveable into the container to an actuated position where a predetermined amount of the pharmaceutical formulation is released. A contact member is provided in the housing. In one version, the contact member is moveable between a first position and a second position to allow for selective actuation of the metering valve. In another version, the contact member's configuration may be changed to allow for selective actuation of the metering valve.
Inventor(s): Schuler; Carlos A. (Cupertino, CA), Alston; William (San Jose, CA)
Assignee: Novartis AG (Basel, CH)
Filing Date:Dec 10, 2003
Application Number:10/734,076
Claims:1. An aerosolization device comprising: a housing; a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant; a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move within the housing, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position; and a contact member in the housing, the contact member being moveable between a first position and a second position, wherein a portion of the metering valve is able to contact the contact member when in the first position and is unable to contact the contact member when in the second position.

2. An aerosolization device according to claim 1 wherein the metering valve may be moved to the actuated position only when the contact member is in the first position.

3. An aerosolization device according to claim 1 wherein the container and the metering valve are moveable within the housing and wherein when the contact member is in the first position, the metering valve is able to contact the contact member so that is may be moved into the container to the actuated position and when the contact member is in the second position, the metering valve is unable to contact the contact member and cannot be moved into the container to the actuated position.

4. An aerosolization device according to claim 1 further comprising a controller adapted to selectively control the movement of the contact member.

5. An aerosolization device according to claim 1 wherein the container moves within the housing when a force is applied by the user directly to a surface of the container.

6. An aerosolization device according to claim 1 wherein the container moves within the housing when a force is applied to an intermediate member.

7. An aerosolization device comprising: a housing; a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant; a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move within the housing, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position; and a contact member in the housing, the contact member having a first configuration and a second configuration, wherein a portion of the metering valve is able to contact the contact member when in the first configuration in a manner which allows the metering valve to be moved to the actuated position, and wherein a portion of the metering valve is able to contact the contact member when in the second configuration in a manner which does not allow the metering valve to be moved to the actuated position.

8. An aerosolization device according to claim 7 wherein the metering valve may be moved to the actuated position only when the contact member is in the first configuration.

9. An aerosolization device according to claim 7 wherein the container and the metering valve are moveable within the housing and wherein when the contact member is in the first configuration, the metering valve is able to contact the contact member so that is may be moved into the container to the actuated position and when the contact member is in the second position, the metering valve is able to contact the contact member but cannot be moved into the container to the actuated position.

10. An aerosolization device according to claim 7 wherein the contact member is rigid in the first configuration and is flexible in the second configuration.

11. An aerosolization device according to claim 7 further comprising a controller adapted to selectively control the configuration of the contact member.

12. An aerosolization device comprising: a housing; a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant; a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move within the housing, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position; and a contact member in the housing, the contact member being moveable from a first condition to a second condition, wherein when the contact member is in the first condition, the metering valve may contact the contact member so as to allow the metering valve to be moved to the actuated position, and wherein a portion of the metering valve is able to contact the contact member when in the second condition in a manner which does not allow the metering valve to be moved to the actuated position.

13. An aerosolization device according to claim 12 wherein the first condition is a first position and wherein the second condition is a second position.

14. An aerosolization device according to claim 13 wherein first position is a position in the housing where the contact member may contact a portion of the metering valve.

15. An aerosolization device according to claim 12 wherein the first condition is a first configuration and wherein the second condition is a second configuration, and wherein the first configuration is a rigid configuration.

16. An aerosolization device according to claim 15 wherein the second configuration is a relatively flexible configuration.

17. An aerosolization device according to claim 12 wherein the metering valve may be moved to the actuated position only when the contact member is in the first condition.

18. An aerosolization device according to claim 12 wherein the container and the metering valve are moveable within the housing and wherein when the contact member is in the first condition, the metering valve is able to contact the contact member so that is may be moved into the container to the actuated position and when the contact member is in the second condition, the metering valve cannot be moved into the container to the actuated position.

19. An aerosolization device according to claim 12 further comprising a controller adapted to selectively control the condition of the contact member.

20. An aerosolization device comprising: a housing; a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant; a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move within the housing, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position; and a contact member in the housing, wherein the metering valve may be moved to the actuated position when the metering valve and/or the container is able to contact the contact member and may not be actuated when the metering valve and/or the container is unable to contact the contact member.

21. An aerosolization device according to claim 20 further comprising a controller adapted to selectively control when the metering valve may and may not be moved to the actuated position.

22. An aerosolization device comprising: a housing; a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant; a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move within the housing, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position; and a contact member in the housing, wherein the metering valve may be moved to the actuated position when the metering valve and/or the container is able to contact the contact member in a rigid configuration and may not be actuated when the metering valve and/or the container is unable to contact the contact member in a rigid configuration.

23. An aerosolization device according to claim 22 further comprising a controller adapted to selectively control when the metering valve may and may not be moved to the actuated position.

24. A method of controlling the operation of an aerosolization device, the aerosolization device comprising a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and the aerosolization device comprising a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position, the method comprising: positioning a contact member in a first position where the contact member may contact the metering valve and/or the container to allow the metering valve to be moved to the actuated position; and positioning the contact member in a second position where the metering valve may not be moved to the actuated position.

25. A method according to claim 24 wherein the second position is a position where the contact member may not be contacted by the metering valve or the container.

26. A method according to claim 24 comprising returning the contact member to the first position after a condition is met.

27. A method according to claim 26 wherein the condition is the passage of a predetermined amount of time.

28. A method of controlling the operation of an aerosolization device, the aerosolization device comprising a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and the aerosolization device comprising a metering valve in communication with the reservoir, the metering valve being moveable into the container to an actuated position when a user applies a force to the container to cause the container to move, wherein a predetermined amount of the pharmaceutical formulation is released when the metering valve is moved to the actuated position, the method comprising: configuring a contact member in a first configuration wherein the contact member may contact the metering valve to allow the metering valve to be moved to the actuated position; and configuring the contact member in a second configuration wherein the metering valve may contact the contact member but may not be moved to the actuated position.

29. A method according to claim 28 wherein the first configuration is a rigid configuration.

30. A method according to claim 28 wherein the second configuration is a flexible configuration.

31. A method according to claim 28 comprising returning the contact member to the first configuration after a condition is met.

32. A method according to claim 31 wherein the condition is the passage of a predetermined amount of time.
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