Details for Patent: 7,893,100
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Title: | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
Abstract: | The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc. |
Inventor(s): | Brook; Christopher S. (King of Prussia, PA), Chen; Wei (Woodbury, MN), Dell'Orco; Philip C. (King Of Prussia, PA), Katrincic; Lee M. (King Of Prussia, PA), Louvet; Ann Marie (King Of Prussia, PA), Oh; Choon K. (Oaks, PA), Spoors; Paul G. (King Of Prussia, PA), Werner; Christopher (King of Prussia, PA) |
Assignee: | SB Pharmco Puerto Rico Inc. (Hato Rey, PR) |
Filing Date: | Jun 25, 2007 |
Application Number: | 11/767,578 |
Claims: | 1. A compound which is carvedilol dihydrogen phosphate methanol solvate. 2. The compound according to claim 1 having an x-ray diffraction pattern which comprises characteristic peaks in degrees two-theta (2.theta.) as shown in FIG. 24. 3. A compound which is carvedilol dihydrogen phosphate methanol solvate having characteristic peaks from 0.degree. degrees 2-theta (2.theta.) to 35.degree. degrees 2-theta (2.theta.) at about 6.9.+-.0.2 (2.theta.), 7.2.+-.0.2 (2.theta.), 13.5.+-.0.2 (2.theta.), 14.1.+-.0.2 (2.theta.), 17.8.+-.0.2 (2.theta.), and 34.0.+-.0.2 (2.theta.). 4. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier. 5. A method of treating hypertension, congestive heart failure or angina which comprises administering to a subject in need thereof an effective amount of the compound according to claim 1. 6. A method of treating hypertension, congestive heart failure or angina which comprises administering to a subject in need thereof an effective amount of the composition according to claim 4. |