Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

Federal Trade Commission
Colorcon
Farmers Insurance
Chinese Patent Office
McKinsey
Novartis
Dow
Johnson and Johnson
Covington
Citi

Generated: August 18, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title:Antisense modulation of apolipoprotein B expression
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
Inventor(s): Crooke; Rosanne M. (Carlsbad, CA), Graham; Mark J. (San Clemente, CA)
Assignee: Genzyme Corporation (Cambridge, MA)
Filing Date:Aug 01, 2001
Application Number:09/920,033
Claims:1. An oligonucleotide 12 to 30 nucleobases in length, or a salt thereof, targeted to a nucleic acid molecule encoding apolipoprotein B, wherein the oligonucleotide is 100% complementary to SEQ ID NO: 3 and wherein the oligonucleotide comprises at least 8 consecutive nucleobases of SEQ ID NO:27.

2. The oligonucleotide of claim 1 comprising at least one modified nucleobase.

3. The oligonucleotide of claim 2 wherein the modified nucleobase is a 5-methylcytosine.

4. The oligonucleotide of claim 1 wherein the oligonucleotide is a chimeric oligonucleotide.

5. The oligonucleotide of claim 1, wherein the oligonucleotide inhibits the expression of the long form of apolipoprotein B, ApoB-100.

6. The oligonucleotide of claim 1, wherein the oligonucleotide comprises a modified sugar moiety.

7. The oligonucleotide of claim 6, wherein the modified sugar moiety is a 2' substituted sugar moiety or a bicyclic sugar moiety.

8. The oligonucleotide of claim 7, wherein the 2' substituted sugar moiety is a 2'-O-methoxyethyl sugar moiety.

9. The oligonucleotide of claim 7, wherein the bicyclic sugar moiety is a locked nucleic acid.

10. The oligonucleotide of claim 7, wherein the bicyclic sugar moiety has a (--CH.sub.2--).sub.n group forming a bridge between the 2' oxygen and the 4' carbon atoms of the sugar ring, wherein n is 1 or 2.

11. The oligonucleotide of claim 1, wherein the oligonucleotide comprises at least one modified internucleoside linkage.

12. The oligonucleotide of claim 11, wherein the modified internucleoside linkage is a phosphorothioate linkage.

13. The oligonucleotide of claim 1, having i. a gap segment of ten linked 2'-deoxynucleosides, ii. a 5' wing segment of five linked nucleosides, and iii. a 3' wing segment of five linked nucleosides, wherein the gap segment is positioned between the 5' wing segment and the 3' wing segment, wherein each nucleoside of each wing segment comprises a 2'-O-methoxyethyl sugar modification, and wherein each internucleoside linkage is a phosphorothioate internucleoside linkage.

14. The oligonucleotide of claim 13, the oligonucleotide comprising at least one cytosine, wherein each cytosine is a 5-methylcytosine.

15. The oligonucleotide of claim 1, wherein the oligonucleotide comprises 20 nucleobases.

16. The oligonucleotide of claim 15, wherein the oligonucleotide consists of 20 nucleobases.

17. The oligonucleotide of claim 1, wherein the oligonucleotide is an oligonucleotide salt.

18. The oligonucleotide of claim 15, wherein the salt is a sodium salt.

19. A composition comprising the oligonucleotide of claim 1 and a pharmaceutically acceptable carrier or diluent.

20. The composition of claim 19 further comprising a colloidal dispersion system.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
Healthtrust
Covington
Federal Trade Commission
Novartis
Colorcon
US Army
Argus Health
Medtronic
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot