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|Title:||Platelet derived growth factor (PDGF) nucleic acid ligand complexes|
|Abstract:||This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.|
|Inventor(s):||Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO)|
|Assignee:||Gilead Sciences, Inc. (Foster City, CA)|
|Filing Date:||Aug 01, 2007|
|Claims:||1. A nucleic acid ligand to PDGF comprising the sequence: TABLE-US-00010 (SEQ ID NO:146) CAGGC A G-N-CGTAGAGCA A-N-TGAT G[3'T] |
wherein A,C,G,T=deoxy-A,C,G,T; A,C,G,U=2'-OMe-A,C,G,T; C,U=2'-fluoro-C,U; N is from hexaethyleneglycol phosphoramidite; and [3'T]=inverted (3'-3') T.
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