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Generated: November 22, 2017

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Title:Platelet derived growth factor (PDGF) nucleic acid ligand complexes
Abstract: This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more PDGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a PDGF Nucleic Acid Ligand or Complex and methods for making the same.
Inventor(s): Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Filing Date:Aug 01, 2007
Application Number:11/832,411
Claims:1. A nucleic acid ligand to PDGF comprising the sequence: TABLE-US-00010 (SEQ ID NO:146) CAGGC A G-N-CGTAGAGCA A-N-TGAT G[3'T]

wherein A,C,G,T=deoxy-A,C,G,T; A,C,G,U=2'-OMe-A,C,G,T; C,U=2'-fluoro-C,U; N is from hexaethyleneglycol phosphoramidite; and [3'T]=inverted (3'-3') T.
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