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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
Daiichi Sankyo
US Department of Justice
Johnson and Johnson
US Army

Generated: April 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,854,920

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Title:Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
Abstract: This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Inventor(s): Klunk; William E. (Pittsburgh, PA), Mathis, Jr.; Chester A. (Pittsburgh, PA), Wang; Yanming (Imperial, PA)
Assignee: University of Pittsburgh (Pittsburgh, PA)
Filing Date:Jul 26, 2007
Application Number:11/828,554
Claims:1. A compound having structure 6: ##STR00027##

2. A pharmaceutical composition comprising the compound having structure 6: ##STR00028## and a pharmaceutically acceptable carrier.

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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Fish and Richardson
Argus Health
Federal Trade Commission

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