Details for Patent: 7,838,563

Title:	Compounds, formulations, and methods for ameliorating telangiectasias
Abstract:	Methods, compounds, and topical formulations for treatment of telangiectasias are disclosed. The methods comprise topically applying a composition comprising an .alpha.-adrenergic receptor agonist to telangiectatic skin. Amelioration of telangiectasia symptoms begins within minutes after topical application of a disclosed composition. A single application can significantly lessen telangiectasia discoloration for at least about 2 hours.
Inventor(s):	DeJovin; Jack A. (New Brunswick, NJ), DeJovin; Isabelle Jean (New Brunswick, NJ), Powala; Christopher (Radnor, PA)
Assignee:	Galderma Laboratories Inc. (Fort Worth, TX)
Filing Date:	Jun 08, 2006
Application Number:	11/449,079
Claims:	1. A method of ameliorating a telangiectasia, the method comprising topically administering to an affected area of skin of a subject in need thereof a therapeutically effective amount of a composition comprising at least one .alpha.-adrenergic receptor agonist, a pharmaceutically acceptable salt thereof, or a combination thereof. 2. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is an agonist selective for an .alpha.1-adrenergic receptor. 3. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is an agonist selective for an .alpha.2-adrenergic receptor. 4. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is a non-selective .alpha.-adrenergic receptor agonist. 5. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is brimonidine. 6. The method in accordance with claim 1, wherein the composition further comprises at least one pharmaceutically acceptable carrier. 7. The method in accordance with claim 6, wherein the composition is of a form selected from the group consisting of a spray, a low-viscosity aqueous liquid, an alcoholic liquid, a mist, an aerosol, a lotion, a gel, a cream, an ointment, a foam, a paste, an unguent, an emulsion, a liposomal suspension, a colloid and a combination thereof. 8. The method in accordance with claim 1, wherein the therapeutically effective amount for amelioration of a telangiectasia is an amount locally effective for amelioration of the telangiectasia. 9. The method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist, a pharmaceutically acceptable salt thereof, or a combination thereof is a first active ingredient, and the composition further comprises a second active ingredient. 10. The method in accordance with claim 9, wherein the second active ingredient is selected from the group consisting of an antibiotic, a non-antibiotic chemically modified tetracycline, a steroid, a retinoid, and an anti-fungal agent. 11. The method in accordance with claim 10, wherein the antibiotic is selected from the group consisting of clindamycin, doxycycline, erythromycin, metronidazole, sulfacetamide and tetracycline. 12. The method in accordance with claim 9, wherein the second active ingredient is selected from the group consisting of azelaic acid, benzoyl peroxide, isotretinoin, an antibiotic, a pharmaceutically acceptable salt thereof and a combination thereof. 13. The method in accordance with claim 1, further comprising systemically administering an antibiotic. 14. The method in accordance with claim 13, wherein the antibiotic is selected from the group consisting of clindamycin, doxycycline, erythromycin, metronidazole, sulfacetamide and tetracycline. 15. The method of claim 1, wherein the telangiectasia is not associated with rosacea. 16. The method of claim 1 wherein the telangiectasia is a telangiectasia associated with at least one of age, sun exposure, alcohol use, scleroderma, hereditary hemorrhagic telangiectasia (Olser-Rendu syndrome), Ataxia-Telangiectasia, spider angioma, cutis marmorata telangiectasia congenita, Bloom syndrome, Klippel-Trenaunay-Weber syndrome, Sturge-Weber disease, Xeroderma pigmentosa, Nevus flammeus, Generalized essential telangiectasias (GET), angioma serpiginosum, ataxia telangiectasia, spider naevi, CREST Syndrome, hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu Syndrome), ataxia-telangiectasia, basal cell carcinoma, scleroderma, unilateral nevoid telangiectasia, and cutis marmorata telangiectatica congenita. 17. The method of claim 1 wherein the telangiectasia is a telangiectasia associated with rosacea. 18. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is selected from the group consisting of oxymetazoline, tetrahydrozoline, naphazoline, xylometazoline, phenylephrine, methoxamine, mephentermine, metaraminol, midodrine, epinephrine, and norepinephrine. 19. A method in accordance with claim 1, wherein the at least one .alpha.-adrenergic receptor agonist is oxymetazoline. 20. A method of ameliorating [visible small, red, purple, or blue surface blood vessels] swelling of blood vessels, enlarged, dilated and/or visible spider veins, and red, purple or blue patches on the skin resulting from dilated blood vessels associated with telangiectasia, the method comprising topically administering to an affected area of skin of a subject in need thereof a therapeutically effective amount of a composition comprising at least one .alpha.-adrenergic receptor agonist, a pharmaceutically acceptable salt thereof, or a combination thereof.