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Generated: January 19, 2018

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Title:Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
Abstract: The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof, wherein said dual serotonin norepinephrine reuptake inhibitor compound is characterized by a non-tricyclic structure and an equal or greater inhibition of norepinephrine reuptake than serotonin reuptake. In particular, the use of milnacipran to treat FMS, CFS, and pain is disclosed.
Inventor(s): Kranzler; Jay D. (La Jolla, CA), Rao; Srinivas G. (San Diego, CA)
Assignee: Cypress Bioscience, Inc. (San Diego, CA)
Filing Date:Jul 18, 2003
Application Number:10/623,431
Claims:1. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof i) an effective amount of at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof; and ii) an effective amount of at least one additional compound selected from pregabalin, a pharmaceutically acceptable salt of pregabalin, or a combination thereof; with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.

2. The method of claim 1, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are in the same dosage form.

3. The method of claim 1, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are in separate dosage forms.

4. The method of claim 3, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are administered simultaneously.

5. The method of claim 3, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are administered separately.

6. The method of claim 2, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are in the same oral dosage form.

7. The method of claim 3, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof and at least one additional compound are in separate oral dosage forms.

8. The method of claim 1, wherein the at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof is in tablet form.
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