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Details for Patent: 7,786,102

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Details for Patent: 7,786,102

Title:Steroids as agonists for FXR
Abstract: The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
Inventor(s): Pellicciari; Roberto (Perugia, IT)
Assignee: Intercept Pharmaceuticals, Inc. (New York, NY)
Filing Date:Nov 21, 2006
Application Number:11/602,307
Claims:1. A method for activating FXR in a mammal comprising administering to the mammal, in an amount effective for activating FXR, a compound: ##STR00007## or a pharmaceutically acceptable salt or amino acid conjugate thereof, wherein said mammal is in need of treatment of an FXR mediated disease, further wherein said disease is cholestatic liver disease.

2. The method according to claim 1, wherein the compound is a pharmaceutically acceptable salt of the compound.

3. The method according to claim 1, wherein the compound is the amino acid conjugate of the compound.
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