|Title:||Steroids as agonists for FXR|
|Abstract:|| The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.|
|Inventor(s):|| Pellicciari; Roberto (Perugia, IT) |
|Assignee:|| Intercept Pharmaceuticals, Inc. (New York, NY) |
|Filing Date:||Nov 21, 2006|
|Claims:||1. A method for activating FXR in a mammal comprising administering to the mammal, in an amount effective for activating FXR, a compound: ##STR00007## or a pharmaceutically acceptable salt or amino acid conjugate thereof, wherein said mammal is in need of treatment of an FXR mediated disease, further wherein said disease is cholestatic liver disease. |
2. The method according to claim 1, wherein the compound is a pharmaceutically acceptable salt of the compound.
3. The method according to claim 1, wherein the compound is the amino acid conjugate of the compound.