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Details for Patent: 7,776,881

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Details for Patent: 7,776,881

Title:Hyperlipemia therapeutic agent
Abstract: A hypertriglyceridemia therapeutic agent made up of a synergistically effective blood-triglyceride decreasing amount of a combination of a pitavastatin and eicosapentaenoic acid (EPA), or an ester thereof.
Inventor(s): Aoki; Taro (Tokorozawa, JP), Yamaguchi; Junji (Higashimurayama, JP), Sasaki; Yusuke (Higashimurayama, JP)
Assignee: Kowa Co., Ltd. (Nagoya-shi, JP) Nissan Chemical Industries, Ltd. (Tokyo, JP)
Filing Date:Dec 05, 2005
Application Number:11/293,217
Claims:1. A hypertriglyceridemia therapeutic agent comprising a synergistically effective blood-triglyceride decreasing amount of a combination of a pitavastatin and eicosapentaenoic acid (EPA) or an ester thereof.

2. The therapeutic agent according to claim 1, wherein the pitavastatin is pitavastatin calcium and the eciosapentaenoic acid (EPA) or ester thereof is ethyl eicosapentaenoate.

3. The therapeutic agent of claim 1, wherein the eicosapentaenoic acid or an ester thereof is selected from the group consisting of the calcium salt of EPA, the sodium salt of EPA, the n-butyl ester of EPA, the isobutyl ester of EPA, the t-butyl ester of EPA, the glycerin ester of EPA, the ethyl ester of EPA, and combinations thereof.

4. The therapeutic agent of claim 1, wherein the eicosapentaenoic acid or an ester thereof is selected from the group consisting of the calcium salt of EPA, the sodium salt of EPA, the n-butyl ester of EPA, the isobutyl ester of EPA, the t-butyl ester of EPA, the glycerin ester of EPA, and combinations thereof.

5. The therapeutic agent of claim 1, wherein the ratio of pitavastatin to EPA or an ester thereof is 1:100.

6. The therapeutic composition of claim 5, comprising 1 to 20 mg of pitavastatin.

7. The therapeutic composition of claim 1, wherein the ratio of pitavastatin to EPA or an ester thereof is 1:100 to 1:2000.
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