Details for Patent: 7,759,384

Title:	Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment
Abstract:	The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
Inventor(s):	Brook; Christopher S. (King of Prussia, PA), Chen; Wei (Woodbury, MN), Dell'orco; Philip C. (King of Prussia, PA), Katrincic; Lee M. (King of Prussia, PA), Louvet; Ann Marie (King of Prussia, PA), Oh; Choon K. (Oaks, PA), Spoors; Paul G. (King of Prussia, PA), Werner; Christopher (King of Prussia, PA)
Assignee:	SmithKline Beecham (Cork) Limited (Currabinny, Carrigaline, County Cork, IE)
Filing Date:	Jun 25, 2007
Application Number:	11/767,581
Claims:	1. A compound which is carvedilol dihydrogen phosphate having an x-ray diffraction pattern which comprises characteristic peaks in degrees two-theta (2.theta.) as shown in FIG. 28. 2. A compound which is carvedilol dihydrogen phosphate having characteristic peaks from 0.degree. degrees 2-theta (2.theta.) to 35.degree. degrees 2-theta (2.theta.) at about 13.2.+-.0.2 (2.theta.), 15.8.+-.0.2 (2.theta.), 16.3.+-.0.2 (2.theta.), 21.2.+-.0.2 (2.theta.), 23.7.+-.0.2 (2.theta.), and 26.0.+-.0.2 (2.theta.). 3. A method of treating hypertension, congestive heart failure or angina which comprises administering to a subject in need thereof an effective amount of the compound according to claim 1. 4. A method of treating hypertension, congestive heart failure or angina which comprises administering to a subject in need thereof an effective amount of the compound according to claim 2.