Details for Patent: 7,741,338
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Title: | Macrolides |
Abstract: | The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form. |
Inventor(s): | Navarro; Francois (Bruebach, FR), Petit; Samuel (Mont Saint-Aignan, FR), Stone; Guy (Crosshaven, IE) |
Assignee: | Novartis AG (Basel, CH) |
Filing Date: | Jul 06, 2009 |
Application Number: | 12/497,728 |
Claims: | 1. A solid mixture comprising 40-O-(2-hydroxy)ethyl-rapamycin and 2,6-di-tert-butyl-methylphenol (BHT). 2. A mixture according to claim 1, wherein said 2,6-di-tert-butyl-4-methylphenol (BHT) is present in a catalytic amount. 3. A pharmaceutical composition comprising the solid mixture of claim 1 together with one or more pharmaceutically acceptable diluent or carrier. |