|Abstract:||The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.|
|Inventor(s):||Cho; Wing-Kee Philip (Princeton, NJ)|
|Assignee:||Schering Corporation (Kenilworth, NJ)|
|Filing Date:||May 26, 2009|
|Claims:||1. A pharmaceutical composition comprising: (a) from 1% to 20% by weight of a cholesterol absorption inhibitor; (b) from 1% to 80% by weight of at least one HMG-CoA reductase inhibitor; (c) from 0.005% to 10% by weight of ascorbic acid; (d) croscarmellose sodium; and (e) povidone. |
2. The pharmaceutical composition according to claim 1, wherein the cholesterol absorption inhibitor is ezetimibe.
3. The pharmaceutical composition according to claim 1, wherein the HMG-Co-A reductase inhibitor is simvastatin or atorvastatin.