|Title:||Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis|
|Abstract:|| Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.|
|Inventor(s):|| von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
|Assignee:|| Wellstat Therapeutics Corporation (Gaithersburg, MD) |
|Filing Date:||Apr 24, 2003|
|Claims:||1. A method of treating cachexia comprising administering to an animal having cachexia a therapeutically effective amount of triacetyluridine. |
2. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase selected from the group consisting of 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-methoxybenzylacetylacyclobarbiturate, 2,2'-anhydro-5-ethyluridine, benzylacyclouridine, benzyloxybenzylacyclouridine, aminomethyl-benzylacyclouridine, aminomethylbenzyloxybenzylacyclouridine, hydroxymethylbenzylacyclouridine and hydroxymethyl-benzyloxybenzylacyclouridine.