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Generated: August 17, 2017

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Title:Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
Inventor(s): von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD)
Assignee: Wellstat Therapeutics Corporation (Gaithersburg, MD)
Filing Date:Apr 24, 2003
Application Number:10/421,831
Claims:1. A method of treating cachexia comprising administering to an animal having cachexia a therapeutically effective amount of triacetyluridine.

2. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase selected from the group consisting of 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-methoxybenzylacetylacyclobarbiturate, 2,2'-anhydro-5-ethyluridine, benzylacyclouridine, benzyloxybenzylacyclouridine, aminomethyl-benzylacyclouridine, aminomethylbenzyloxybenzylacyclouridine, hydroxymethylbenzylacyclouridine and hydroxymethyl-benzyloxybenzylacyclouridine.
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Serving 500+ biopharmaceutical companies globally:

QuintilesIMS
Cantor Fitzgerald
Harvard Business School
AstraZeneca
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Merck
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Julphar
Johnson and Johnson
Fuji

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