Details for Patent: 7,709,459
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Title: | Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis |
Abstract: | Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed. |
Inventor(s): | von Borstel; Reid W. (Potomac, MD), Bamat; Michael K. (Potomac, MD), Hiltbrand; Bradley M. (Columbia, MD) |
Assignee: | Wellstat Therapeutics Corporation (Gaithersburg, MD) |
Filing Date: | Apr 24, 2003 |
Application Number: | 10/421,831 |
Claims: | 1. A method of treating cachexia comprising administering to an animal having cachexia a therapeutically effective amount of triacetyluridine. 2. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase selected from the group consisting of 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-methoxybenzylacetylacyclobarbiturate, 2,2'-anhydro-5-ethyluridine, benzylacyclouridine, benzyloxybenzylacyclouridine, aminomethyl-benzylacyclouridine, aminomethylbenzyloxybenzylacyclouridine, hydroxymethylbenzylacyclouridine and hydroxymethyl-benzyloxybenzylacyclouridine. |