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Details for Patent: 7,696,220

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Details for Patent: 7,696,220

Title:Methods for the treatment or inhibition of ileus
Abstract: Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.
Inventor(s): Farrar; John J. (Chester Springs, PA), Schied; Peter J. (Southampton, PA), Schmidt; William K. (Newark, DE), Carpenter; Randall L. (Waban, MA)
Assignee: Adolor Corporation (Exton, PA)
Filing Date:Jun 13, 2002
Application Number:10/171,299
Claims:1. A method of treating or inhibiting ileus comprising administering to a patient an effective amount of a peripheral mu opioid antagonist compound, wherein said peripheral mu opioid antagonist compound is the quaternary morphinan compound N-methylnaltrexone.

2. A method according to claim 1 wherein the ileus is selected from the group consisting of postsurgical ileus and postpartum ileus.

3. A method according to claim 2 wherein the ileus is post-surgical ileus.

4. A method according to claim 3 wherein said postsurgical ileus is postsurgical paralytic ileus.

5. A method according to claim 1 wherein the ileus is ileus of the colon.

6. A method according to claim 1 wherein the ileus occurs in the absence of exogenous opioid agonists.

7. A method according to claim 1 further comprising administering an opiate or an opioid to said patient.

8. A method according to claim 7 wherein said opiate or opioid comprises an opioid analgesic.

9. A method according to claim 8 wherein said opioid analgesic comprises a mu opioid agonist.

10. A method according to claim 1 further comprising administering to said patient a compound which slows gut motility.
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