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|Title:||Methods for the treatment or inhibition of ileus|
|Abstract:||Methods for the treatment of ileus are disclosed wherein the peripheral mu opioid antagonist methylnaltrexone is administered.|
|Inventor(s):||Farrar; John J. (Chester Springs, PA), Schied; Peter J. (Southampton, PA), Schmidt; William K. (Newark, DE), Carpenter; Randall L. (Waban, MA)|
|Assignee:||Adolor Corporation (Exton, PA)|
|Filing Date:||Jun 13, 2002|
|Claims:||1. A method of treating or inhibiting ileus comprising administering to a patient an effective amount of a peripheral mu opioid antagonist compound, wherein said peripheral mu opioid antagonist compound is the quaternary morphinan compound N-methylnaltrexone. |
2. A method according to claim 1 wherein the ileus is selected from the group consisting of postsurgical ileus and postpartum ileus.
3. A method according to claim 2 wherein the ileus is post-surgical ileus.
4. A method according to claim 3 wherein said postsurgical ileus is postsurgical paralytic ileus.
5. A method according to claim 1 wherein the ileus is ileus of the colon.
6. A method according to claim 1 wherein the ileus occurs in the absence of exogenous opioid agonists.
7. A method according to claim 1 further comprising administering an opiate or an opioid to said patient.
8. A method according to claim 7 wherein said opiate or opioid comprises an opioid analgesic.
9. A method according to claim 8 wherein said opioid analgesic comprises a mu opioid agonist.
10. A method according to claim 1 further comprising administering to said patient a compound which slows gut motility.
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