Details for Patent: 7,683,087

Title:	N[S(4-aryl-triazol-3-yl).alpha.-mercaptoacetyl] -p-amino benzoic acids as HIV reverse transcriptase inhibitors
Abstract:	A series of S-triazolyl .alpha.-mercaptoacetanilides having N-(.alpha.-mercaptoacetyl) p amino benzoic acid derivatives. ##STR00001## are provided, where Q is CO.sub.2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
Inventor(s):	Girardet; Jean-Luc (Aliso Viejo, CA), de la Rosa; Martha (Fountain Valley, CA), Hong; Zhi (Chapel Hill, NC), Lang; Stanley (Laguna Niguel, CA)
Assignee:	Ardea Biosciences, Inc. (San Diego, CA)
Filing Date:	Aug 18, 2008
Application Number:	12/193,599
Claims:	1. A compound of formula ##STR00105## wherein: Ar is ##STR00106## R.sup.1 is selected from the group consisting of Cl, Br, I, CH.sub.3, CF.sub.3, CHF.sub.2, and CH.sub.2F; X is O or NH; R.sup.2 is H, a pharmaceutically acceptable cation or C.sub.1-3 alkyl, when X is O; or XR.sup.2 is NHCH.sub.2CH.sub.2COOR.sup.13 or NHCH(R.sup.12)COOR.sup.13 where R.sup.12 is C.sub.1-4 alkyl or aryl-C.sub.1-4 alkyl and R.sup.13 a pharmaceutically acceptable cation or C.sub.1-3 alkyl; R.sub.3 is H or CH.sub.3; R.sup.0 is selected from the group consisting of Cl, Br, CF.sub.3 and methyl; R.sup.P is selected from the group consisting of methyl, ethyl, propyl, isopropyl, cyclopropylmethyl, and C.sub.3-6 cycloalkyl; R.sup.6 is H, F, Cl, Br, CH.sub.3, CF.sub.3, CFH.sub.2, CF.sub.2H, ethyl, isopropyl, cyclopropyl, OCH.sub.3, OH, OCF.sub.3, NH.sub.2 or NHCH.sub.3; and R.sup.7 is selected from the group consisting of Cl, Br, I, CH.sub.3, CF.sub.3; OCH.sub.3, isopropyl, cyclopropyl, tert-butyl, cyclobutyl, and methyl. 2. The compound of claim 1, wherein X is O. 3. The compound of claim 2, wherein R.sup.6 is not OH, NH.sub.2 or NHCH.sub.3. 4. The compound of claim 2, wherein Ar is not substituted phenyl and at least one of R.sup.4, R.sup.5, and R.sup.6 is other than H or CH.sub.3. 5. The compound of claim 1, which is 4-[2-(5-bromo-4-[2-chloro-4-cyclopropyl-6-methylphenyl]-4H-1,2,4-triazol-- 3-ylthio)acetamido]-3-chlorobenzoic acid or an ester or a pharmaceutically acceptable salt thereof. 6. The compound of claim 1, wherein R.sup.2 is H. 7. The compound of claim 3, wherein Ar is a substituted quinoline or isoquinoline and R.sup.1 is selected from the group consisting of Br, CF.sub.3, CFH.sub.2, and CF.sub.2H. 8. The compound of claim 7, wherein each of R.sup.4, R.sup.5, and R.sup.6 is H. 9. The compound of claim 7, wherein R.sup.P is cyclopropyl. 10. The compound of claim 7, wherein R.sup.1 is Br and R.sup.0 is Cl. 11. The compound of claim 1, wherein R.sup.2 is H or a pharmaceutically acceptable cation. 12. The compound of claim 1, wherein R.sup.1 is Cl or Br. 13. The compound of claim 12, wherein R.sup.1 is Br. 14. The compound of claim 1, wherein R.sup.1 is Br, CF.sub.3, CFH.sub.2 or CF.sub.2H. 15. The compound of claim 14, wherein R.sup.1 is CF.sub.2H. 16. The compound of claim 1, wherein R.sup.3 is H. 17. The compound of claim 1, wherein R.sup.0 is Cl. 18. The compound of claim 1, wherein R.sup.0 is Cl and X is O. 19. The compound of claim 1, wherein R.sup.6 is not H or CH.sub.3. 20. The compound of claim 1, wherein R.sup.P is alkyl. 21. The compound of claim 20, wherein R.sup.P is methyl. 22. The compound of claim 1, wherein R.sup.P is C.sub.3-6 cycloalkyl. 23. The compound of claim 22, wherein R.sup.P is cyclopropyl. 24. The compound of claim 1, wherein R.sup.6 is not H. 25. The compound of claim 1, wherein R.sup.6 is H, Cl, CH.sub.3, CF.sub.3 or ethyl. 26. The compound of claim 1, wherein R.sup.7 is Cl, CH.sub.3 or CF.sub.3. 27. The compound of claim 1, wherein R.sup.1 is Br or CF.sub.2H; R.sup.3 is H; R.sup.0 is Cl; and R.sup.2 is H or a pharmaceutically acceptable cation. 28. The compound of claim 27, wherein R.sup.P is C.sub.3-6 cycloalkyl. 29. The compound of claim 28, wherein R.sup.P is cyclopropyl. 30. The compound of claim 1, wherein at least one of R.sup.6 or R.sup.7 is not H. 31. The compound of claim 30, wherein R.sup.6 is H and R.sup.7 is Cl, Br, CH.sub.3 or CF.sub.3. 32. The compound of claim 1, wherein R.sup.6 and R.sup.7 are each independently selected from Cl, Br, CH.sub.3 and CF.sub.3. 33. The compound of claim 1, wherein R.sup.6 is not H. 34. The compound of claim 33, wherein R.sup.6 in the ortho position, relative to the triazole ring. 35. The compound of claim 1, wherein R.sup.6 and R.sup.7 are both not H. 36. The compound of claim 35, wherein R.sup.6 and R.sup.7 are both in the ortho position, relative to the triazole ring.