Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Find generic entry opportunities
Manage your formulary budget
Proactively manage your pharmacy inventory
Drug patents …
… from Kazakhstan to Kalamazoo
Anticipate generic drug launch
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||N-terminally chemically modified protein compositions and methods|
|Abstract:||Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.|
|Inventor(s):||Kinstler; Olaf B. (Thousand Oaks, CA), Gabriel; Nancy Elise (Thousand Oaks, CA), Farrar; Christine E. (Newbury Park, CA), DePrince; Randolph B. (Raleigh, NC)|
|Assignee:||Amgen Inc. (Thousand Oaks, CA)|
|Filing Date:||Apr 26, 2006|
|Claims:||1. A method of treating a hematopoietic disorder, wherein the hematopoietic disorder is a result of a reduced neutrophil count, comprising administering a therapeutically effective dose of a substantially homogeneous preparation of N-terminally monopegylated granulocyte colony stimulating factor (G-CSF) or an analog thereof pegylated via an amine linkage optionally in a pharmaceutically acceptable diluent, carrier, or adjuvant. |
2. The method of claim 1, wherein the hematopoietic disorder is a result of an infectious disease.
3. The method of claim 2, wherein the infectious disease is a bacterial, viral, or fungal infectious disease.
4. The method of claim 2, wherein the infectious disease is sepsis.
5. The method of claim 1, wherein the hematopoietic disorder is a result of chemotherapy.
6. The method of claim 1, wherein the hematopoietic disorder is a result of radiation therapy.
7. The method of claim 1, wherein the hematopoietic disorder is severe chronic neutropenia or a leukemia.
8. The method of claim 1, wherein the therapeutically effective dose is in a range of 0.01 .mu.g/kg body weight to 100 .mu.g/kg body weight.
9. The method of claim 1, wherein the polyethylene glycol has a molecular weight of 2 kDa to 100 kDa.
10. The method of claim 9, wherein the polyethylene glycol has a molecular weight of 6 kDa to 25 kDa.
11. The method of claim 10, wherein the polyethylene glycol has a molecular weight of 20 kDa.
12. The method of claim 1, wherein the preparation comprises at least 90% N-terminally-modified G-CSF or analog thereof and at most 10% unpegylated G-CSF or analog thereof.
13. The method of claim 12, wherein the preparation comprises at least 95% N-terminally-modified G-CSF or analog thereof and at most 5% unpegylated G-CSF or analog thereof.
14. The method of claim 1, wherein the G-CSF or analog thereof is not glycosylated.
15. The method of claim 1, wherein the G-CSF or analog thereof has a methionine at the N-terminus.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.