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Details for Patent: 7,659,268

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Details for Patent: 7,659,268

Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Hadida-Ruah; Sara (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Oceanside, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA), van Goor; Frederick (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Cambridge, MA)
Filing Date:May 18, 2007
Application Number:11/804,726
Claims:1. A compound selected from the following: TABLE-US-00012 423 ##STR00703## 424 ##STR00704## 425 ##STR00705## 426 ##STR00706## 427 ##STR00707## 428 ##STR00708## 429 ##STR00709## 430 ##STR00710## 431 ##STR00711## 432 ##STR00712## 433 ##STR00713## 434 ##STR00714## 435 ##STR00715## 436 ##STR00716## 437 ##STR00717## 438 ##STR00718## 439 ##STR00719## 440 ##STR00720## 441 ##STR00721## 442 ##STR00722## 443 ##STR00723## 444 ##STR00724## 445 ##STR00725## 446 ##STR00726## 447 ##STR00727## 448 ##STR00728## 449 ##STR00729## 450 ##STR00730## 451 ##STR00731## 452 ##STR00732## 453 ##STR00733## 454 ##STR00734## 455 ##STR00735## 456 ##STR00736## 457 ##STR00737## 458 ##STR00738## 459 ##STR00739## 460 ##STR00740## 461 ##STR00741## 462 ##STR00742## 463 ##STR00743## 465 ##STR00744## 466 ##STR00745## 467 ##STR00746## 468 ##STR00747## 469 ##STR00748## 470 ##STR00749## 471 ##STR00750## 472 ##STR00751## 473 ##STR00752## 474 ##STR00753## 475 ##STR00754## 476 ##STR00755## 477 ##STR00756## 478 ##STR00757## 479 ##STR00758## 480 ##STR00759## 481 ##STR00760## 482 ##STR00761## 483 ##STR00762## 484 ##STR00763## 485 ##STR00764## 486 ##STR00765## 487 ##STR00766## 488 ##STR00767## 489 ##STR00768## 490 ##STR00769## 491 ##STR00770## 492 ##STR00771## 493 ##STR00772## 494 ##STR00773## 495 ##STR00774## 496 ##STR00775## 497 ##STR00776## 498 ##STR00777## 499 ##STR00778## 500 ##STR00779## 501 ##STR00780## 502 ##STR00781## 503 ##STR00782## 504 ##STR00783## 505 ##STR00784## 506 ##STR00785##

507 ##STR00786## 508 ##STR00787## 509 ##STR00788## 510 ##STR00789## 511 ##STR00790## 512 ##STR00791## 513 ##STR00792## 514 ##STR00793## 515 ##STR00794## 516 ##STR00795## 517 ##STR00796## 518 ##STR00797## 519 ##STR00798## 520 ##STR00799## 521 ##STR00800## 522 ##STR00801## 523 ##STR00802## 524 ##STR00803## 525 ##STR00804## 526 ##STR00805## 527 ##STR00806## 528 ##STR00807##

2. A pharmaceutical composition comprising: (i) a compound according to claim 1; and (ii) a pharmaceutically acceptable carrier.

3. The composition according to claim 2, further comprising a mucolytic agent, a bronchodialator, an antibiotic, an anti-infective agent, an anti-inflammatory agent, a CFTR modulator, or a nutritional agent.
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