Details for Patent: 7,649,019
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Title: | Modified release formulations of a bupropion salt |
Abstract: | The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition. |
Inventor(s): | Oberegger; Werner (Mississauga, CA), Zhou; Fang (Davie, FL), Maes; Paul (Toronto, CA), Jackson; Graham (Co. Kildare, IE), Saleh; Mohammad Ashty (Oakville, CA) |
Assignee: | Biovail Laboratories International S.R.L. (St. Michael, BB) |
Filing Date: | Jun 07, 2007 |
Application Number: | 11/759,413 |
Claims: | 1. A composition comprising bupropion hydrobromide and at least one controlled release polymer that reduces the ratio of the maximum/minimum plasma bupropion hydrobromide concentration (Cmax/Cmin) while maintaining bupropion plasma levels within the therapeutic window upon administration to a patient. 2. A composition comprising bupropion hydrobromide and and at least one controlled release polymer that controls the release of the bupropion hydrobromide upon administration to a patient to provide plasma concentrations of the bupropion hydrobromide within a therapeutic range over a 24 hour period. 3. A composition comprising bupropion hydrobromide and at least one controlled release polymer that releases the bupropion hydrobromide upon administration to a patient to provide a time delay between administration and the commencement of bupropion hydrobromide-release in the external environment of use. |