Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Methods for the treatment of cachexia and graft v. host disease|
|Abstract:||Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF.alpha. in a mammal.|
|Inventor(s):||Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)|
|Assignee:||Celgene Corporation (Summit, NJ)|
|Filing Date:||Nov 17, 2005|
|Claims:||1. A method of treating cachexia or graft v. Host disease comprising administering to a patient in need of such treatment an effective amount of 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline: ##STR00007## or a salt or stereoisomer thereof. |
2. The method of claim 1, wherein a substantially chirally pure (S) or (R) isomer is administered.
3. The method of claim 1, wherein 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, or a salt or stereoisomer thereof, is administered orally or parenterally.
4. The method of claim 1, wherein cachexia is treated.
5. The method of claim 1, wherein graft v. host disease is treated.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.