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|Title:||Methods for the treatment of cachexia and graft v. host disease|
|Abstract:||Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNF.alpha. in a mammal.|
|Inventor(s):||Muller; George W. (Bridgewater, NJ), Stirling; David I. (Branchburg, NJ), Chen; Roger Shen-Chu (Edison, NJ)|
|Assignee:||Celgene Corporation (Summit, NJ)|
|Filing Date:||Nov 17, 2005|
|Claims:||1. A method of treating cachexia or graft v. Host disease comprising administering to a patient in need of such treatment an effective amount of 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline: ##STR00007## or a salt or stereoisomer thereof. |
2. The method of claim 1, wherein a substantially chirally pure (S) or (R) isomer is administered.
3. The method of claim 1, wherein 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, or a salt or stereoisomer thereof, is administered orally or parenterally.
4. The method of claim 1, wherein cachexia is treated.
5. The method of claim 1, wherein graft v. host disease is treated.