Details for Patent: 7,626,041
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Title: | Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment |
Abstract: | The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc. |
Inventor(s): | Brook; Christopher S. (King of Prussia, PA), Chen; Wei (Woodbury, MN), Dell'orco; Philip C. (King of Prussia, PA), Katrincic; Lee M. (King of Prussia, PA), Louvet; Ann Marie (King of Prussia, PA), Oh; Choon K. (Oaks, PA), Spoors; Paul G. (King of Prussia, PA), Werner; Christopher (King of Prussia, PA) |
Assignee: | SmithKline Beecham (Cork) Ltd (County Cork, IE) |
Filing Date: | Jun 25, 2007 |
Application Number: | 11/767,573 |
Claims: | 1. A compound which is carvedilol dihydrogen phosphate dihydrate having an x-ray diffraction pattern which comprises characteristic peaks in degrees two-theta (2.theta.) as shown in FIG. 9. 2. A compound which is carvedilol dihydrogen phosphate dihydrate having characteristic peaks from 0.degree. degrees 2-theta (2.theta.) to 35.degree. degrees 2-theta (2.theta.) at about 6.5.+-.0.2 (2.theta.), 7.1.+-.0.2 (2.theta.), 13.5 .+-.0.2 (2.theta.), 14.0.+-.0.2 (2.theta.), 17.8.+-.0.2 (2.theta.), 18.9.+-.0.2 (2.theta.), and 21.0.+-.0.2 (2.theta.). 3. A compound which is carvedilol dihydrogen phosphate dihydrate having an x-ray diffraction pattern which comprises characteristic peaks in degrees two-theta (2.theta.) as shown in FIG. 25. 4. A compound which is carvedilol dihydrogen phosphate dihydrate having characteristic peaks from 0.degree. degrees 2-theta (2.theta.) to 35.degree. degrees 2-theta (2.theta.) at about 6.4.+-.0.2 (2.theta.), 9.6.+-.0.2 (2.theta.), 16.0 .+-.0.2 (2.theta.), 18.4.+-.0.2 (2.theta.), 20.7.+-.0.2 (2.theta.), and 24.5.+-.0.2 (2.theta.). |