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Details for Patent: 7,625,861

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Details for Patent: 7,625,861

Title:Copolymer-1 improvements in compositions of copolymers
Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Inventor(s): Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)
Assignee: Yeda Research and Development Co., Ltd. (Rehovot, IL)
Filing Date:Jan 23, 2007
Application Number:11/656,505
Claims:1. A process for preparing a copolymer-1 composition having a target average molecular weight comprising: providing a first copolymer-1 composition having an average molecular weight greater than the target average molecular weight; removing a sufficient amount of copolymer species having a molecular weight greater than the target average molecular weight to obtain a second copolymer-1 composition having the target average molecular weight; wherein the target average molecular weight falls within the range of about 4 to about 8.6 kDa.

2. The process of claim 1, wherein the number of copolymer species having a molecular weight greater than 40 kDa in the second copolymer-1 composition is less than half the number of copolymer species having a molecular weight greater than 40 kDa in the first copolymer-1 composition.

3. The process of claim 1, further comprising isolating the second copolymer-1 composition.

4. The process of claim 1, wherein the removing of copolymer species having a molecular weight greater than the target average molecular weight comprises physically separating copolymer species having a molecular weight greater than the target average molecular weight.

5. The process of claim 4, wherein the physically separating step comprises chromatographic separation.

6. The process of claim 1, wherein the removing of copolymer species having a molecular weight greater than the target average molecular weight comprises cleaving copolymer species having a molecular weight greater than the target average molecular weight.

7. The process of claim 5, wherein the cleaving step comprises acid hydrolysis.

8. The process of claim 6, further comprising isolating the second copolymer-1 composition by dialysis or ultrafiltration of the result of the cleaving step.

9. The process of claim 5, wherein the cleaving step comprises enzymatic hydrolysis.

10. The process of claim 8, further comprising isolating the second copolymer-1 composition by dialysis or ultrafiltration of the result of the cleaving step.

11. The process of claim 5, further comprising isolating the second copolymer-1 composition by dialysis or ultrafiltration of the result of the cleaving step.
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