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Details for Patent: 7,585,838

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Details for Patent: 7,585,838

Title:Methods of treating fibromyalgia caused by small intestinal bacterial overgrowth
Abstract: Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.
Inventor(s): Lin; Henry C. (Albuquerque, NM), Pimentel; Mark (Los Angeles, CA)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Filing Date:Aug 14, 2007
Application Number:11/838,631
Claims:1. A method of treating fibromyalgia in a subject who has small intestinal bacterial overgrowth (SIBO), comprising: providing a composition comprising a therapeutic agent selected from the group consisting of an antimicrobial agent, an antibiotic, and combinations thereof; and administering the composition to the subject who has SIBO in an amount sufficient to at least partially eradicate SIBO in the subject who has SIBO, whereby the at least partial eradication of SIBO treats fibromyalgia.

2. The method of claim 1, wherein the antimicrobial agent is selected from the group consisting of neomycin, metronidazole, teicoplanin, ciprofloxacin, doxycycline, tetracycline, augmentin, cephalexin, penicillin, ampicillin, kanamycin, rifamycin, vancomycin, rifaximin, and combinations thereof.

3. The method of claim 1, wherein the antibiotic is rifaximin.

4. A method of treating fibromyalgia in a subject who has small intestinal bacterial overgrowth (SIBO), comprising: providing a composition comprising rifaximin; and administering the composition to the subject who has SIBO in an amount sufficient to at least partially eradicate SIBO in the subject who has SIBO, whereby the at least partial eradication of SIBO treats fibromyalgia.

5. The method of claim 1, wherein the administering results in complete eradication of the small intestinal bacterial overgrowth.

6. The method of claim 1, wherein the administering results in improvement of symptoms in fibromyalgia.

7. The method of claim 6, wherein the symptoms are joint pain and/or fatigue.

8. The method of claim 3, wherein the rifaximin is administered orally.

9. The method of claim 3, wherein the composition comprises a unitized amount of rifaximin.

10. The method of claim 3, wherein the rifaximin is dehydrated rifaximin.

11. The method of claim 3, where in the rifaximin is lyophilized rifaximin.

12. The method of claim 4, wherein the rifaximin is administered orally.

13. The method of claim 4, wherein the composition comprises a unitized amount of rifaximin.

14. The method of claim 4, wherein the rifaximin is dehydrated rifaximin.

15. The method of claim 4, where in the rifaximin is lyophilized rifaximin.

16. The method of claim 4, wherein the administering results in complete eradication of the small intestinal bacterial overgrowth.

17. The method of claim 4, wherein the administering results in improvement of symptoms in fibromyalgia.

18. The method of claim 17, wherein the symptoms are joint pain and/or fatigue.
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