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Generated: December 16, 2017

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Title:Proteasome inhibitors and methods of using the same
Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
Inventor(s): Bernardini; Raffaella (Calci, IT), Oliva; Ambrogio (Saronno, IT)
Assignee: Cephalon, Inc. (Frazer, PA)
Filing Date:Aug 12, 2004
Application Number:10/918,664
Claims:1. Boronic acid, [(1R)-1-[[(2S,3R)-3-hydroxy-2-[(6-phenyl-pyridine-2-carbonyl)amino]-1-oxo- butyl]amino]-3-methylbutyl], or a pharmaceutically acceptable salt thereof.
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