Details for Patent: 7,541,024
✉ Email this page to a colleague
| Title: | Low salt forms of polyallylamine |
| Abstract: | Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent. |
| Inventor(s): | Petersen; John S. (Acton, MA), Burke; Steven K. (Sudbury, MA), Holmes-Farley; Stephen Randall (Arlington, MA) |
| Assignee: | Genzyme Corporation (Cambridge, MA) |
| Filing Date: | Apr 17, 2002 |
| Application Number: | 10/125,684 |
| Claims: | 1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a stable polyallylamine hydrochloride polymer wherein between about 4% to about 12% by weight of the polymer is chloride anion and between about 9.0% to about 27.0% of the amine groups in the polyallylamine polymer are protonated. 2. The pharmaceutical composition of claim 1 wherein between about 5% to about 9% by weight of the polymer is chloride anion. 3. The pharmaceutical composition of claim 2 wherein the polymer is a homopolymer. 4. The pharmaceutical composition of claim 3 wherein the polyallylamine hydrochloride polymer comprises a repeat unit represented by Structural Formula (I): ##STR00003## 5. The pharmaceutical composition of claim 4 wherein the polymer is crosslinked. 6. The pharmaceutical composition of claim 5 wherein the polymer is crosslinked with 2-hydroxypropyl crosslinking groups. 7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a stable polyallylamine homopolymer comprising repeat units represented by Structural Formula (I): ##STR00004## wherein the homopolymer is crosslinked with 2-hydroxypropyl groups, between about 9% and about 30% of the amine groups in the homopolymer are bonded to one of the 2-hydroxypropyl crosslinking groups, and between about 5% and about 9% by weight of the homopolymer is chloride anion and between about 9.0% to about 27.0% of the amine groups in the polyallylamine polymer are protonated. |
