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Details for Patent: 7,541,024

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Details for Patent: 7,541,024

Title:Low salt forms of polyallylamine
Abstract: Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.
Inventor(s): Petersen; John S. (Acton, MA), Burke; Steven K. (Sudbury, MA), Holmes-Farley; Stephen Randall (Arlington, MA)
Assignee: Genzyme Corporation (Cambridge, MA)
Filing Date:Apr 17, 2002
Application Number:10/125,684
Claims:1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a stable polyallylamine hydrochloride polymer wherein between about 4% to about 12% by weight of the polymer is chloride anion and between about 9.0% to about 27.0% of the amine groups in the polyallylamine polymer are protonated.

2. The pharmaceutical composition of claim 1 wherein between about 5% to about 9% by weight of the polymer is chloride anion.

3. The pharmaceutical composition of claim 2 wherein the polymer is a homopolymer.

4. The pharmaceutical composition of claim 3 wherein the polyallylamine hydrochloride polymer comprises a repeat unit represented by Structural Formula (I): ##STR00003##

5. The pharmaceutical composition of claim 4 wherein the polymer is crosslinked.

6. The pharmaceutical composition of claim 5 wherein the polymer is crosslinked with 2-hydroxypropyl crosslinking groups.

7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a stable polyallylamine homopolymer comprising repeat units represented by Structural Formula (I): ##STR00004## wherein the homopolymer is crosslinked with 2-hydroxypropyl groups, between about 9% and about 30% of the amine groups in the homopolymer are bonded to one of the 2-hydroxypropyl crosslinking groups, and between about 5% and about 9% by weight of the homopolymer is chloride anion and between about 9.0% to about 27.0% of the amine groups in the polyallylamine polymer are protonated.
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