Details for Patent: 7,531,535

Title:	Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
Abstract:	The present application describes lactam-containing compounds and derivatives thereof of Formula I: ##STR00001## or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
Inventor(s):	Pinto; Donald J. P. (Churchville, PA), Qiao; Jennifer X. (Princeton, NJ)
Assignee:	Bristol-Meyers Squibb Company (Princeton, NJ)
Filing Date:	Dec 13, 2007
Application Number:	11/955,678
Claims:	1. A compound of Formula I: P.sub.4--P-M-M.sub.4 I or a stereoisomer or pharmaceutically acceptable salt thereof, wherein: M is a cyclohexyl group substituted with 0-3 R.sup.1a and 0-2 carbonyl groups; P is absent, P.sub.4 is directly attached to ring M, and P.sub.4 and M.sub.4 are attached to the 1,2, 1,3, or 1,4 positions of ring M; one of P.sub.4 and M.sub.4 is -Z-A-B and the other -G.sub.1-G; G is a group of Formula IIa or IIb: ##STR00226## ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; ring D is substituted with 0-2 R and there are 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2 R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent and ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, triazolyl, thienyl, and thiazolyl, and ring E is substituted with 1 R and with a 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, wherein the 5-6 membered heterocycle is substituted with 0-1 carbonyl and 1-2 R and there are 0-3 ring double bonds; R is selected from H, C.sub.1-4 alkyl, F, Cl, Br, I, OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, OCH.sub.2CH.sub.2CH.sub.3, CN, C(.dbd.NR.sup.8)NR.sup.7R.sup.9, NHC(.dbd.NR.sup.8)NR.sup.7R.sup.9, ONHC(.dbd.NR.sup.8)NR.sup.7R.sup.9, NR.sup.8CH(.dbd.NR.sup.7), NH.sub.2, NH(C.sub.1-3 alkyl), N(C.sub.1-3 alkyl).sub.2, C(.dbd.NH)NH.sub.2, CH.sub.2NH.sub.2, CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2N(C.sub.1-3 alkyl).sub.2, CH.sub.2CH.sub.2NH.sub.2, CH.sub.2CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2CH.sub.2N(C.sub.1-3 alkyl).sub.2, (CR.sup.8R.sup.9).sub.tC(O)H, (CR.sup.8R.sup.9).sub.tC(O).sub.r.sup.2c, (CR.sup.8R.sup.9).sub.tNR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tC(O)NR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tNR.sup.7C(O).sub.r.sup.7, (CR.sup.8R.sup.9).sub.tOR.sup.3, (CR.sup.8R.sup.9).sub.tS(O).sub.pNR.sup.7R.sup.8, (CR.sup.8R.sup.9).sub.tNR.sup.7S(O).sub.pR.sup.7, (CR.sup.8R.sup.9).sub.tSR.sup.3, (CR.sup.8R.sup.9).sub.tS(O)R.sup.3, (CR.sup.8R.sup.9).sub.tS(O).sub.2R.sup.3, and OCF.sub.3; alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; A is a phenylene group; B is ##STR00227## provided that Z and B are attached to different atoms on A and that B is other than triazolone, quinolone, or isoquinolone, wherein the triazolone, quinolone, and isoquinolone groups are substituted or unsubstituted; Q.sub.1 is C.dbd.O; ring Q is a 4-8 membered monocyclic or bicyclic ring consisting of, in addition to the N-Q.sub.1 group shown, carbon atoms and 0-2 heteroatoms selected from NR.sup.4c, O, S, S(O), and S(O).sub.2, wherein: 0-2 double bonds are present within the ring and the ring is substituted with 0-2 R.sup.4a; alternatively, ring Q is a 4-8 membered monocyclic or bicyclic ring to which another ring is fused, wherein: the 4-8 membered ring consists of, in addition to the shown amide group, carbon atoms and 0-2 heteroatoms selected from NR.sup.4c, O, S, S(O), and S(O).sub.2, and 0-2 double bonds are present within the ring; the fusion ring is phenyl or a 5-6 membered heteroaromatic consisting of carbon atoms and 1-2 heteroatoms selected from NR.sup.4c, O, S, S(O), and S(O).sub.2; ring Q, which includes the 4-7 membered ring and the fusion ring, is substituted with 0-3 R.sup.4a; alternatively, two non-adjacent atoms of one of the rings of ring Q are bridged with 1-2 atoms selected from: carbon atoms, NR.sup.4c, O, S, S(O), and S(O).sub.2, provided bonds other than O--O, S(O).sub.p--O, S(O).sub.p--S(O).sub.p, N--O, and N--S(O).sub.p are present; X is absent; G.sub.1 and Z are each --(C.dbd.O)NH--, where N is attached to ring M; R.sup.1a, at each occurrence, is selected from H, --(CR.sup.3R.sup.3a).sub.r--R.sup.1b, --(CR.sup.3R.sup.3a).sub.r--CR.sup.3R.sup.1bR.sup.1b, --(CR.sup.3R.sup.3a).sub.r--O--(CR.sup.3R.sup.3a).sub.r--R.sup.1b, C.sub.2-6 alkenylene-R.sup.1b, --C.sub.2-6 alkynylene-R.sup.1b, --(CR.sup.3R.sup.3a).sub.r--C(.dbd.NR.sup.1b)NR.sup.3R.sup.1b, NR.sup.3CR.sup.3R.sup.3aR.sup.1c, OCR.sup.3R.sup.3aR.sup.1c, SCR.sup.3R.sup.3aR.sup.1c, NR.sup.3(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, C(O)NR.sup.2(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, CO.sub.2(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, O(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, S(CR.sup.3R.sup.3a).sub.2(CR.sup.3R.sup.3a).sub.tR.sup.1b, S(O).sub.p(CR.sup.3R.sup.3a).sub.rR.sup.1d, O(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, OC(O)NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3C(O)NR.sup.3(CR.sup.3R.sup.3a).sub.rR.sup.1d, NR.sup.3C(O)O(CR.sup.3R.sup.3a).sub.rR.sup.1d, and NR.sup.3C(O)(CR.sup.3R.sup.3a).sub.rR.sup.1d, provided that R.sup.1a forms other than an N-halo, N--S, O--O, or N--CN bond; alternatively, when two R.sup.1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-7 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, this ring being substituted with 0-2 R.sup.4b and 0-3 ring double bonds; R.sup.1b is selected from H, C.sub.1-3 alkyl, F, Cl, Br, I, --CN, --NO.sub.2, --CHO, (CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.rOR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, OC(O)R.sup.2, (CF.sub.2).sub.rCO.sub.2R.sup.2a, S(O).sub.pR.sup.2b, NR.sup.2(CH.sub.2).sub.rOR.sup.2, C(.dbd.NR.sup.2c)NR.sup.2R.sup.2a, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NHR.sup.2, NR.sup.2C(O).sub.2R.sup.2a, OC(O)NR.sup.2R.sup.2a, C(O)NR.sup.2R.sup.2a, C(O)NR.sup.2(CH.sub.2).sub.rOR.sup.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, C(O)NR.sup.2SO.sub.2R.sup.2, C.sub.3-6 carbocycle substituted with 0-2 R.sup.4b, and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1b forms other than an O--O, N-halo, N--S, or N--CN bond; R.sup.1c is selected from H, CH(CH.sub.2OR.sup.2).sub.2, C(O)R.sup.2c, C(O)NR.sup.2R.sup.2a, S(O)R.sup.2, S(O).sub.2R.sup.2, and SO.sub.2NR.sup.2R.sup.2a; R.sup.1d is selected from C.sub.3-6 carbocycle substituted with 0-2 R.sup.4b and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1d forms other than an N--S bond; R.sup.2, at each occurrence, is selected from H, CF.sub.3, C.sub.1-6 alkyl, benzyl, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CF.sub.3, C.sub.1-6 alkyl, benzyl, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from CF.sub.3, C.sub.1-4 alkoxy substituted with 0-2 R.sup.4b, C.sub.1-6 alkyl substituted with 0-2 R.sup.4b, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2c, at each occurrence, is selected from CF.sub.3, OH, C.sub.1-4 alkoxy, C.sub.1-6 alkyl, --(CH.sub.2).sub.r--C.sub.3-10 carbocycle substituted with 0-2 R.sup.4b, and --(CH.sub.2).sub.r-5-10 membered heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.3, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; R.sup.3a, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; alternatively, R.sup.3 and R.sup.3a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially unsaturated, or unsaturated ring consisting of: carbon atoms, the nitrogen atom to which R.sup.3 and R.sup.3a are attached, and 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.3c, at each occurrence, is selected from CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, and phenyl; R.sup.3d, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C.sub.1-4 alkyl-phenyl, and C(.dbd.O)R.sup.3c; R.sup.4a, at each occurrence, is selected from H, .dbd.O, (CR.sup.3R.sup.3a).sub.rOR.sup.2, (CR.sup.3R.sup.3a).sub.rF, (CR.sup.3R.sup.3a).sub.rBr, (CR.sup.3R.sup.3a).sub.rCl, C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rCN, (CR.sup.3R.sup.3a).sub.rNO.sub.2, (CR.sup.3R.sup.3a).sub.rNR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)R.sup.2c, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)R.sup.2b, (CR.sup.3R.sup.3a).sub.rC(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rN.dbd.CHOR.sup.3, (CR.sup.3R.sup.3a).sub.rC(O)NH(CH.sub.2).sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2C(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rSO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rC(O)NHSO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rNR.sup.2SO.sup.2R.sup.5, (CR.sup.3R.sup.3a).sub.rS(O).sub.pR.sup.5a, (CR.sup.3R.sup.3a).sub.r(CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.r-5-6 membered carbocycle substituted with 0-1 R.sup.5, and a (CR.sup.3R.sup.3a).sub.r-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4b, at each occurrence, is selected from H, .dbd.O, (CH.sub.2).sub.rOR.sup.3, (CH.sub.2).sub.rF, (CH.sub.2).sub.rCl, (CH.sub.2).sub.rBr, (CH.sub.2).sub.rI, C.sub.1-4 alkyl, (CH.sub.2).sub.rCN, (CH.sub.2).sub.rNO.sub.2, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.r--C(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.r--C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rSO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2--C.sub.1-4 alkyl, (CH.sub.2).sub.rNR.sup.3SO.sub.2CF.sub.3, (CH.sub.2).sub.rNR.sup.3SO.sub.2-phenyl, (CH.sub.2).sub.rS(O).sub.pCF.sub.3, (CH.sub.2).sub.rS(O).sub.p--C.sub.1-4 alkyl, (CH.sub.2).sub.rS(O).sub.p-phenyl, and (CH.sub.2).sub.r(CF.sub.2).sub.rCF.sub.3; R.sup.4c, at each occurrence, is selected from H, C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.r1OR.sup.2, (CR.sup.3R.sup.3a).sub.r1F, (CR.sup.3R.sup.3a).sub.r1Br, (CR.sup.3R.sup.3a).sub.r1Cl, (CR.sup.3R.sup.3a).sub.r1CN, (CR.sup.3R.sup.3a).sub.r1NO.sub.2, (CR.sup.3R.sup.3a).sub.r1NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rC(O)R.sup.2c, (CR.sup.3R.sup.3a).sub.r1NR.sup.2C(O)R.sup.2b, (CR.sup.3R.sup.3a).sub.rC(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1N.dbd.CHOR.sup.3, (CR.sup.3R.sup.3a).sub.rC(O)NH(CH.sub.2).sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2C(O)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1C(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NHC(.dbd.NR.sup.2)NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.rSO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2NR.sup.2R.sup.2a, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.rC(O)NHSO.sub.2--C.sub.1-4 alkyl, (CR.sup.3R.sup.3a).sub.r1NR.sup.2SO.sub.2R.sup.5, (CR.sup.3R.sup.3a).sub.rS(O).sub.pR.sup.5a, (CR.sup.3R.sup.3a).sub.r(CF.sub.2).sub.rCF.sub.3, (CR.sup.3R.sup.3a).sub.r-5-6 membered carbocycle substituted with 0-1 R.sup.5, and a (CR.sup.3R.sup.3a).sub.r-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, C.sub.1-6 alkyl, .dbd.O, (CH.sub.2).sub.rOR.sup.3, F, Cl, Br, I, --CN, NO.sub.2, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.rC(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(O)NR.sup.3R.sup.3a, (CH.sub.2).sub.rCH(.dbd.NOR.sup.3d), (CH.sub.2).sub.rC(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, (CH.sub.2).sub.rSO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2NR.sup.3R.sup.3a, (CH.sub.2).sub.rNR.sup.3SO.sub.2--C.sub.1-4 alkyl, (CH.sub.2).sub.rNR.sup.3SO.sub.2CF.sub.3, (CH.sub.2).sub.rNR.sup.3SO.sub.2-phenyl, (CH.sub.2).sub.rS(O).sub.pCF.sub.3, (CH.sub.2).sub.rS(O).sub.p--C.sub.1-4 alkyl, (CH.sub.2).sub.rS(O).sub.p-phenyl, (CF.sub.2).sub.rCF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; R.sup.5a, at each occurrence, is selected from C.sub.1-6 alkyl, (CH.sub.2).sub.rOR.sup.3, (CH.sub.2).sub.rNR.sup.3R.sup.3a, (CH.sub.2).sub.rC(O)R.sup.3, (CH.sub.2).sub.rC(O)OR.sup.3c, (CH.sub.2).sub.rNR.sup.3C(O)R.sup.3a, (CH.sub.2).sub.rC(O)NR.sup.3R.sup.3a, (CF.sub.2).sub.rCF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6, provided that R.sup.5a does not form a S--N or S(O).sub.p--C(O) bond; R.sub.6, at each occurrence, is selected from H, OH, (CH.sub.2).sub.rOR.sup.2, halo, C.sub.1-4 alkyl, CN, NO.sub.2, (CH.sub.2).sub.rNR.sup.2R.sup.2a, (CH.sub.2).sub.rC(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NR.sup.2R.sup.2a, C(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, and NR.sup.2SO.sub.2C.sub.1-4 alkyl; R.sup.7, at each occurrence, is selected from H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkyl-C(O)--, C.sub.1-6 alkyl-O--, (CH.sub.2).sub.n-phenyl, C.sub.1-4 alkyl-OC(O)--, C.sub.6-10 aryl-O--, C.sub.6-10 aryl-OC(O)--, C.sub.6-10 aryl-CH.sub.2-C(O)--, C.sub.1-4 alkyl-C(O)O--C.sub.1-4 alkyl-OC(O)--, C.sub.6-10 aryl-C(O)O--C.sub.1-4 alkyl-OC(O)--, C.sub.1-6 alkyl-NH.sub.2--C(O)--, phenyl-NH.sub.2--C(O)--, and phenyl-C.sub.1-4 alkyl-C(O)--; R.sup.8, at each occurrence, is selected from H, C.sub.1-6 alkyl, and (CH.sub.2).sub.n-phenyl; alternatively, R.sup.7 and R.sup.8, when attached to the same nitrogen, combine to form a 5-10 membered heterocyclic ring consisting of carbon atoms and 0-2 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.9, at each occurrence, is selected from H, C.sub.1-6 alkyl, and (CH.sub.2).sub.n-phenyl; n, at each occurrence, is selected from 0, 1, 2, and 3; p, at each occurrence, is selected from 0, 1, and 2; r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5, and 6; r1, at each occurrence, is selected from 1, 2, 3, 4, 5, and 6; and t, at each occurrence, is selected from 0, 1, 2, and 3. 2. A compound according to claim 1, wherein G is a group of Formula IIa or IIb: ##STR00228## ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p; ring D is substituted with 0-2 R and there are 0-3 ring double bonds; E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 1-2 R; alternatively, ring D is absent, and ring E is selected from phenyl, pyridyl, pyrimidyl, and thienyl, and ring E is substituted with 1-2 R; alternatively, ring D is absent, ring E is selected from phenyl, pyridyl, and thienyl, and ring E is substituted with 1 R and substituted with a 5 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, wherein the 5 membered heterocycle is substituted with 0-1 carbonyl and 1-2 R and there are 0-3 ring double bonds; R is selected from H, C.sub.1-4 alkyl, F, Cl, OH, OCH.sub.3, OCH.sub.2CH.sub.3, OCH(CH.sub.3).sub.2, CN, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, C(.dbd.NH)NHOCH.sub.3, NH.sub.2, NH(C.sub.1-3 alkyl), N(C.sub.1-3 alkyl).sub.2, CH.sub.2NH.sub.2, CH.sub.2NH(C.sub.1-3 alkyl), CH.sub.2N(C.sub.1-3 alkyl).sub.2, (CR.sup.8R.sup.9).sub.tNR.sup.7R.sup.8, C(O)NR.sup.7R.sup.8, CH.sub.2C(O)NR.sup.7R.sup.8, S(O).sub.pNR.sup.7R.sup.8, CH.sub.2S(O).sub.pNR.sup.7R.sup.8, SO.sub.2R.sup.3, and OCF.sub.3; alternatively, when 2 R groups are attached to adjacent atoms, they combine to form methylenedioxy or ethylenedioxy; B is ##STR00229## provided that Z and B are attached to different atoms on A and that B is other than triazolone, quinolone, or isoquinolone, wherein the triazolone, quinolone, and isoquinolone groups are substituted or unsubstituted; Q.sub.1 is; ring Q is a 4-7 membered monocyclic or bicyclic ring consisting of, in addition to the N-Q.sub.1 group shown, carbon atoms and 0-2 heteroatoms selected from NR.sup.4c, O, S, S(O), and S(O).sub.2, wherein: 0-2 double bonds are present within the ring and the ring is substituted with 0-2 R.sup.4a; alternatively, ring Q is a 4-7 membered ring to which another ring is fused, wherein: the 4-7 membered ring consists of, in addition to the shown amide group, carbon atoms and 0-2 heteroatoms selected from NR.sup.4c, O, S, S(O), and S(O).sub.2, and 0-1 double bonds are present within the ring; the fusion ring is phenyl or a 5-6 membered heteroaromatic consisting of carbon atoms and 1-2 heteroatoms selected from NR.sup.4c, O, and S; ring Q, which includes the 4-7 membered ring and the fusion ring, is substituted with 0-3 R.sup.4a; R.sup.1a is selected from H, --(CH.sub.2).sub.r--R.sup.1b, --(CH(CH.sub.3)).sub.r--R.sup.1b, --(C(CH.sub.3).sub.2).sub.r--R.sup.1b, NHCH.sub.2R.sup.1c, OCH.sub.2R.sup.1c, SCH.sub.2R.sup.1c, NH(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, and O(CH.sub.2).sub.2(CH.sub.2).sub.tR.sup.1b, provided that R.sup.1a forms other than an N-halo, N--S, or N--CN bond; alternatively, when two R.sup.1a groups are attached to adjacent atoms, together with the atoms to which they are attached they form a 5-7 membered ring consisting of: carbon atoms and 0-2 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, this ring being substituted with 0-2 R.sup.4b and 0-3 ring double bonds; R.sup.1b is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, F, Cl, Br, I, --CN, --CHO, CF.sub.3, OR.sup.2, NR.sup.2R.sup.2a, C(O)R.sup.2b, CO.sub.2R.sup.2b, OC(O)R.sup.2, CO.sub.2R.sup.2a, S(O).sub.pR.sup.2, NR.sup.2(CH.sub.2).sub.rOR.sup.2, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NHR.sup.2, NR.sup.2C(O).sub.2R.sup.2a, OC(O)NR.sup.2R.sup.2a, C(O)NR.sup.2R.sup.2a, C(O)NR.sup.2(CH.sub.2).sub.rOR.sup.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2R.sup.2, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b, provided that R.sup.1b forms other than an O--O, N-halo, N--S, or N--CN bond; R.sup.1c is selected from H, CH(CH.sub.2OR.sup.2).sub.2, C(O)R.sup.2c, C(O)NR.sup.2R.sup.2a, S(O)R.sup.2, S(O).sub.2R.sup.2, and SO.sub.2NR.sup.2R.sup.2a; R.sup.2, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, a C.sub.5-6 carbocyclic-CH.sub.2-group substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2a, at each occurrence, is selected from H, CF.sub.3, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; alternatively, R.sup.2 and R.sup.2a, together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R.sup.4b and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S(O).sub.p; R.sup.2b, at each occurrence, is selected from CF.sub.3, C.sub.1-4 alkoxy, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.2c, at each occurrence, is selected from CF.sub.3, OH, C.sub.1-4 alkoxy, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, benzyl, C.sub.5-6 carbocycle substituted with 0-2 R.sup.4b, and 5-6 membered heterocycle containing from 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-2 R.sup.4b; R.sup.3, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; R.sup.3a, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; alternatively, R.sup.3 and R.sup.3a, together with the nitrogen atom to which they are attached, combine to form a 5 or 6 membered saturated, partially unsaturated, or unsaturated ring consisting of: carbon atoms and the nitrogen atom to which R.sup.3 and R.sup.3a are attached; R.sup.3c, at each occurrence, is selected from CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, benzyl, and phenyl; R.sup.3d, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2-phenyl, CH.sub.2CH.sub.2-phenyl, and C(.dbd.O)R.sup.3c; R.sup.4a, at each occurrence, is selected from H, .dbd.O, CH.sub.2OR.sup.2, OR.sup.2, CH.sub.2F, F, CH.sub.2Br, Br, CH.sub.2Cl, Cl, C.sub.1-4 alkyl, CH.sub.2--CN, --CN, CH.sub.2NO.sub.2, NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, NR.sup.2R.sup.2a, CH.sub.2--C(O)R.sup.2c, C(O)R.sup.2c, NR.sup.2C(O)R.sup.2b, (CH.sub.2).sub.rC(O)NR.sup.2R.sup.2a, NR.sup.2C(O)NR.sup.2R.sup.2a, (CH.sub.2).sub.rSO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2--C.sub.1-4 alkyl, NR.sup.2SO.sub.2R.sup.5, (CH.sub.2).sub.rS(O).sub.pR.sup.5a, CH.sub.2CF.sub.3, CF.sub.3, CH.sub.2-5-6 membered carbocycle substituted with 0-1 R.sup.5, 5-6 membered carbocycle substituted with 0-1 R.sup.5, and a CH.sub.2-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5, and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.4b, at each occurrence, is selected from H, .dbd.O, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O)R.sup.3, CH.sub.2--C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, CH.sub.2NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, CH.sub.2C(O)NR.sup.3R.sup.3a, NR.sup.3C(O)NR.sup.3R.sup.3a, CH.sub.2NR.sup.3C(O)NR.sup.3R.sup.3a, C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, CH.sub.2C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, CH.sub.2NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, CH.sub.2SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2NR.sup.3R.sup.3a, CH.sub.2NR.sup.3SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, CH.sub.2NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2CF.sub.3, CH.sub.2NR.sup.3SO.sub.2CF.sub.3, NR.sup.3SO.sub.2-phenyl, CH.sub.2NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, CH.sub.2S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, CH.sub.2S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CH.sub.2S(O).sub.pphenyl, CF.sub.3, and CH.sub.2CF.sub.3; R.sup.4c, at each occurrence, is selected from H, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3).sub.3, CH.sub.2OR.sup.2, CH.sub.2F, CH.sub.2Br, CH.sub.2Cl, CH.sub.2CN, CH.sub.2NO.sub.2, CH.sub.2NR.sup.2R.sup.2a, C(O).sub.r.sup.2c, CH.sub.2C(O)R.sup.2c, CH.sub.2NR.sup.2C(O).sub.r2b, C(O)NR.sup.2R.sup.2a, CH.sub.2C(O)NR.sup.2R.sup.2a, CH.sub.2NR.sup.2C(O)NR.sup.2R.sup.2a, SO.sub.2NR.sup.2R.sup.2a, CH.sub.2SO.sub.2NR.sup.2R.sup.2a, CH.sub.2NR.sup.2SO.sub.2NR.sup.2R.sup.2a, CH.sub.2NR.sup.2SO.sub.2--C.sub.1-4 alkyl, C(O)NHSO.sub.2--C.sub.1-4 alkyl, CH.sub.2C(O)NHSO.sub.2--C.sub.1-4 alkyl, CH.sub.2NR.sup.2SO.sub.2R.sup.5, S(O).sub.pR.sup.5a, CH.sub.2S(O).sub.pR.sup.5a, CF.sub.3, CH.sub.2CF.sub.3, 5-6 membered carbocycle substituted with 0-1 R.sup.5, CH.sub.2-5-6 membered carbocycle substituted with 0-1 R.sup.5, 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5, and a CH.sub.2-5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O).sub.p, and substituted with 0-1 R.sup.5; R.sup.5, at each occurrence, is selected from H, .dbd.O, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3)3, OR.sup.3, CH.sub.2OR.sup.3, F, Cl, --CN, NO.sub.2, NR.sup.3R.sup.3a, CH.sub.2NR.sup.3R.sup.3a, C(O).sub.r.sup.3, CH.sub.2C(O)R.sup.3, C(O)OR.sup.3c, CH.sub.2C(O)OR.sup.3c, NR.sup.3C(O)R.sup.3a, C(O)NR.sup.3R.sup.3a, NR.sup.3C(O)NR.sup.3R.sup.3a, CH(.dbd.NOR.sup.3d), C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, NR.sup.3C(.dbd.NR.sup.3)NR.sup.3R.sup.3a, SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2NR.sup.3R.sup.3a, NR.sup.3SO.sub.2--C.sub.1-4 alkyl, NR.sup.3SO.sub.2CF.sub.3, NR.sup.3SO.sub.2-phenyl, S(O).sub.pCF.sub.3, S(O).sub.p--C.sub.1-4 alkyl, S(O).sub.p-phenyl, CF.sub.3, phenyl substituted with 0-2 R.sup.6, naphthyl substituted with 0-2 R.sup.6, and benzyl substituted with 0-2 R.sup.6; and R.sup.6, at each occurrence, is selected from H, OH, OR.sup.2, F, Cl, CH.sub.3, CH.sub.2CH.sub.3, CH.sub.2CH.sub.2CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CH.sub.2CH.sub.2CH.sub.3, CH.sub.2CH(CH.sub.3).sub.2, CH(CH.sub.3)CH.sub.2CH.sub.3, C(CH.sub.3)3, --CN, NO.sub.2, NR.sup.2R.sup.2a, CH.sub.2NR.sup.2R.sup.2a, C(O)R.sup.2b, CH.sub.2C(O)R.sup.2b, NR.sup.2C(O)R.sup.2b, NR.sup.2C(O)NR.sup.2R.sup.2a, C(.dbd.NH)NH.sub.2, NHC(.dbd.NH)NH.sub.2, SO.sub.2NR.sup.2R.sup.2a, NR.sup.2SO.sub.2NR.sup.2R.sup.2a, and NR.sup.2SO.sub.2C.sub.1-4 alkyl. 3. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof. 4. A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof. 5. A method according to claim 4, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart. 6. A method according to claim 4, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from (a) prosthetic valves or other implants, (b) indwelling catheters, (c) stents, (d) cardiopulmonary bypass, (e) hemodialysis, or (f) other procedures in which blood is exposed to an artificial surface that promotes thrombosis. 7. A compound according to claim 1, which is represented by formula (IV): ##STR00230## 8. A compound according to claim 1, which is selected from the group consisting of 3-chloro-N-(1,2-cis-2-{[4-(2-oxopyridin-1(2H)-yl) benzoyl]amino}cyclohexyl)-1H-indole-6-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopyridin-1(2H)-yl)benzoyl]amino}cyclohexyl- )-1H-indole-2-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopyridin-1(2H)-yl)benzoyl]amino}cyclohexyl- )thiophene-2-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopyrazin-1(2H)-yl) benzoyl]amino}cyclohexyl)thiophene-2-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopyrazin-1(2H)-yl)benzoyl]amino}cyclohexyl- )-1H-indole-2-carboxamide; 3-chloro-N-(1,2-cis-2-{[4-(2-oxopyrazin-1(2H)-yl)benzoyl]amino}cyclohexyl- )-1H-indole-6-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopiperidin-1-yl) benzoyl]amino}cyclohexyl)thiophene-2-carboxamide; 5-chloro-N-(1,2-cis-2-{[4-(2-oxopiperidin-1-yl)benzoyl]amino}cyclohexyl)-- 1H-indole-2-carboxamide; and 3-chloro-N-(1,2-cis-2-{[4-(2-oxopiperidin-1-yl)benzoyl]amino}cyclohexyl)-- 1H-indole-6-carboxamide.