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Details for Patent: 7,528,255

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Details for Patent: 7,528,255

Title:Hydroxy, .omega.-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors
Abstract: The invention relates to the use of a group of aryl ureas in treating raf mediated diseases and pharmaceutical compositions for use in such therapy of the formula ##STR00001## wherein, Y is NHR Hal is chlorine or bromine, R is H, CH.sub.3 or CH.sub.2OH, and X.sup.1 to X.sup.7 are each, independently, H, OH or --OC(O)C.sub.1-C.sub.4 alkyl, or a salt purified stereoisomer thereof, wherein at least one of X.sup.1 to X.sup.7 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.
Inventor(s): Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Bethany, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy (Wuppertal, DE), Scott; William (Guilford, CT), Smith; Roger (Madison, CT), Wood; Jill (North Haven, CT)
Assignee: Bayer Pharmaceuticals Corporation (West Haven, CT)
Filing Date:Feb 11, 2002
Application Number:10/071,248
Claims:1. A compound of formula (Ia) ##STR00190## wherein, Y is NHR, Hal is chlorine or bromine, R is H, CH.sub.3 or CH.sub.2OH, and X.sup.1 to X.sup.7 are each, independently, H, OH or --OC(O)C.sub.1-C.sub.4 alkyl, or a salt or purified stereoisomer thereof, with the proviso that at least one of X.sup.1 to X.sup.7 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

2. A compound of claim 1 wherein X.sup.1 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

3. A compound of claim 1 wherein X.sup.2 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

4. A compound of claim 1 wherein X.sup.3 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

5. A compound of claim 1 wherein X.sup.4 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

6. A compound of claim 1 wherein X.sup.5 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

7. A compound of claim 1 wherein X.sup.6 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

8. A compound of claim 1 wherein X.sup.7 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

9. A compound of claim 1 wherein Hal is chlorine.

10. A compound of claim 1 which is 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl)amino]2-(hydroxy)phenoxy}-2-pyridine carboxamide.

11. A compound of claim 1 which is 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]3-(hydro- xy)phenoxy}-2-pyridine carboxamide.

12. A compound of claim 1 which is 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl)amino]5-(hydroxy)phenoxy}-2-pyridine carboxamide.

13. A compound of claim 1 which is 4-{4-[({[4-chloro-3-(trifluoromethyl) phenyl]amino}carbonyl)amino]6-(hydroxy)phenoxy}-2-pyridine carboxamide.

14. A compound of formula (Ib) ##STR00191## wherein, Y is NHR, Hal is chlorine or bromine, R is H, CH.sub.3 or CH.sub.2OH, and X.sup.4 to X.sup.7 are each, independently, H, OH or --OC(O)C.sub.1-C.sub.4 alkyl, or a salt or purified stereoisomer thereof, with the proviso that at least one of X.sup.4 to X.sup.7 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.

15. A compound of formula (Ic) ##STR00192## wherein, Hal is chlorine or bromine, and X.sup.1 to X.sup.7 are each, independently, H, OH or --OC(O)C.sub.1-C.sub.4 alkyl, or a salt or purified stereoisomer thereof, with the proviso that at least one of X.sup.1 to X.sup.7 is OH or --OC(O)C.sub.1-C.sub.4 alkyl.
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