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Generated: October 17, 2017

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Title:Thrombin receptor antagonists
Abstract: A series of compounds represented by the structural formulas ##STR00001## ##STR00002## and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and binders to cannabinoid receptors.
Inventor(s): Chackalamannil; Samuel (Califon, NJ), Chelliah; Mariappan V. (Edison, NJ), Xia; Yan (Edison, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Filing Date:Sep 25, 2003
Application Number:10/671,216
Claims:1. A compound represented by any of the following structural formulas ##STR00237## ##STR00238## or a pharmaceutically acceptable salt thereof.

2. A composition comprising at least one compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

3. A compound represented by the following structural formula: ##STR00239## or a pharmaceutically acceptable salt thereof.

4. A compound represented by the following structural formula ##STR00240## or a pharmaceutically acceptable salt thereof.

5. A compound represented by the following structural formula ##STR00241## or a pharmaceutically acceptable salt thereof.

6. A compound represented by the following structural formula ##STR00242## or a pharmaceutically acceptable salt thereof.

7. A compound represented by the following structural formula ##STR00243## or a pharmaceutically acceptable salt thereof.

8. A compound represented by the following structural formula ##STR00244## or a pharmaceutically acceptable salt thereof.

9. A compound represented by the following structural formula ##STR00245## or a pharmaceutically acceptable salt thereof.

10. A compound represented by the following structural formula ##STR00246## or a pharmaceutically acceptable salt thereof.

11. A compound represented by the following structural formula ##STR00247## or a pharmaceutically acceptable salt thereof.

12. A compound represented by the following structural formula ##STR00248## or a pharmaceutically acceptable salt thereof.

13. A composition comprising a compound represented by the following structural formula ##STR00249## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

14. A composition comprising a compound represented by the following structural formula ##STR00250## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

15. A composition comprising a compound represented by the following structural formula ##STR00251## or a pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier.
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